{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T07:59:21Z","timestamp":1790150361623,"version":"4.0.1"},"reference-count":58,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Pain perception is the result of different modulatory mechanisms. Inhibition, via descending brainstem mechanisms, is key to pain reduction and is typically elicited by the cold pressor test (CPT). Recently, a compensatory hedonic response has been observed after CPT interruption, thought to facilitate return to homeostasis. Although both are triggered by the CPT, how these mechanisms vary across individuals remains unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Pain\u2010free individuals (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009200) participated in a quantitative sensory testing protocol assessing inhibition (via conditioned pain modulation (CPM)) and hedonic (via pleasant pain relief (PPR)) responses. CPM paradigm involved a tonic heat stimulation, administered before and after a CPT at 10\u00b0C. CPM magnitude was calculated as the change in pain ratings following the conditioning stimulus. PPR magnitude was quantified using participants' subjective perception of pain relief immediately following cessation of the CPT. A k\u2010means clustering analysis based on four principal variables was performed to identify distinct response sub\u2010groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Four clusters provided an optimal solution and explained 58% of the total variance. Cluster 1 demonstrated high CPM and moderate PPR response. In contrast, Cluster 2 demonstrated weak CPM and strong PPR. Cluster 3 appears to be similar to Cluster 2. Finally, Cluster 4 was characterized by both weak CPM and weak PPR associated with low pain perception during the CPT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study supports that two distinct phenomena pre\u2010exist, one leading to inhibition and the other to compensation. Although distinct, there appear to be complementary, with the PPR being stronger in individuals with weaker CPM responses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance Statement<\/jats:title>\n                    <jats:p>This study highlights the recruitment of a potential hedonic compensatory mechanism when inhibitory resources are insufficient to cope with pain.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejp.70366","type":"journal-article","created":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T07:16:10Z","timestamp":1787901370000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Conditioned Pain Modulation and Pleasant Pain Relief as Complementary Processes Reflecting Individual Differences in Pain Coping: A Clustering Approach"],"prefix":"10.1002","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7762-1743","authenticated-orcid":false,"given":"Matthieu","family":"Vincenot","sequence":"first","affiliation":[{"name":"Centre de Recherche Institut Universitaire en Sant\u00e9 Mentale de Montr\u00e9al  Montr\u00e9al Qubec Canada"},{"name":"Department of Psychiatry and Addiction, Faculty of Medicine University of Montreal  Montr\u00e9al Qubec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4941-6285","authenticated-orcid":false,"given":"Maxime","family":"Roberge","sequence":"additional","affiliation":[{"name":"Centre de Recherche Institut Universitaire en Sant\u00e9 Mentale de Montr\u00e9al  Montr\u00e9al Qubec Canada"},{"name":"Department of Psychiatry and Addiction, Faculty of Medicine University of Montreal  Montr\u00e9al Qubec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles\u2010\u00c9douard","family":"Gigu\u00e8re","sequence":"additional","affiliation":[{"name":"Centre de Recherche Institut Universitaire en Sant\u00e9 Mentale de Montr\u00e9al  Montr\u00e9al Qubec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1624-378X","authenticated-orcid":false,"given":"St\u00e9phane","family":"Potvin","sequence":"additional","affiliation":[{"name":"Centre de Recherche Institut Universitaire en Sant\u00e9 Mentale de Montr\u00e9al  Montr\u00e9al Qubec Canada"},{"name":"Department of Psychiatry and Addiction, Faculty of Medicine University of Montreal  Montr\u00e9al Qubec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,28]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0297355"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000002203"},{"key":"e_1_2_11_4_1","volume-title":"Manual for the Beck Depression Inventory\u2013II","author":"Beck A. T.","year":"1996"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S248056"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/1935056"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2023.12.001"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/PR9.0000000000001102"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v061.i06"},{"key":"e_1_2_11_10_1","volume-title":"Statistical Power Analysis for the Behavioral Sciences","author":"Cohen J.","year":"1988"},{"issue":"2","key":"e_1_2_11_11_1","first-page":"77","article-title":"Inventaire abr\u00e9g\u00e9 de la d\u00e9pression de Beck (13 Items): \u00c9tude de la validit\u00e9 Concurrente Avec Les \u00e9chelles de Hamilton et de Ralentissement de Widl\u00f6cher [the Shortened Beck Depression Inventory: Study of the Concurrent Validity With the Hamilton Depression Rating Scale and the Widl\u00f6cher Retardation Rating Scale]","volume":"12","author":"Collet L.","year":"1986","journal-title":"L'Enc\u00e9phale: Revue de Psychiatrie Clinique Biologique et Th\u00e9rapeutique"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12859\u2010022\u201004675\u20101"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001664"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2023.115265"},{"issue":"4","key":"e_1_2_11_15_1","first-page":"559","article-title":"Adaptation canadienne\u2010fran\u00e7aise de la forme revis\u00e9e du State\u2010Trait Anxiety Inventory de Spielberger","volume":"25","author":"Gauthier J.","year":"1993","journal-title":"Canadian Journal of Behavioural Science"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2019.09.005"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/PR9.0000000000000999"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40122\u2010024\u201000601\u2010w"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresrev.2008.12.009"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpain.2022.1003237"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci10090599"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/08990220.2016.1229178"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.3352\/jeehp.2021.18.17"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000689"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2012.11.018"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460\u20109568.2008.06380.x"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2333"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000003478"},{"issue":"6","key":"e_1_2_11_29_1","first-page":"454","article-title":"Validation of the French Version of the Snaith\u2010 Hamilton Pleasure Scale (SHAPS, Snaith et\u00a0al. 1995). Determination of the Statistical Parameters in 208 Normal Subjects and 103 Hospitalized Patients Presenting With Depression or Schizophrenia","volume":"23","author":"Loas G.","year":"1997","journal-title":"Encephale"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpain.2020.574370"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/PR9.0000000000000908"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpain.2021.705345"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/AJP.0000000000000296"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2015.09.003"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1515\/sjpain\u20102021\u20100149"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.4741"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2010.05.013"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000573"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010024\u201067401\u20102"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010021\u201083340\u20108"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neucli.2020.11.002"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpain.2025.1677563"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s42979\u2010021\u201000765\u20108"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2017.02.437"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.11613\/BM.2021.010502"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000002719"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.167.1.99"},{"key":"e_1_2_11_48_1","volume-title":"Manual for the State\u2010Trait Anxiety Inventory (Form Y1\u2013Y2)","author":"Spielberger C. D.","year":"1983"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000494"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1097\/PR9.0000000000001425"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2008.06.120"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1515\/sjpain\u20102018\u20100087"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2024.04.008"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0307556"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1097\/AJP.0000000000001320"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2026.106275"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0310839"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.605"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.08.060"}],"container-title":["European Journal of Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ejp.70366","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ejp.70366","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ejp.70366","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T07:00:39Z","timestamp":1790146839000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ejp.70366"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,28]]},"references-count":58,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/ejp.70366"],"URL":"https:\/\/doi.org\/10.1002\/ejp.70366","archive":["Portico"],"relation":{},"ISSN":["1090-3801","1532-2149"],"issn-type":[{"value":"1090-3801","type":"print"},{"value":"1532-2149","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,28]]},"assertion":[{"value":"2026-06-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70366"}}