{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T12:46:32Z","timestamp":1792586792906,"version":"4.5.0"},"reference-count":64,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Chronic pain affects up to 30% of pregnant individuals globally and substantially impairs maternal well\u2010being. The prevalence and contributing factors of\n                      <jats:italic>de novo<\/jats:italic>\n                      chronic pain in pregnancy (DNPAP) remain poorly studied, with previous chronic pain rarely distinguished from newly arising pain. We examined the prevalence and characteristics of DNPAP and its association with foetal and maternal factors, including dysmenorrhea, depressive symptoms and maternal\u2010foetal attachment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cross\u2010sectional study included 207 pregnant women between 30 and 34\u2009weeks of gestation. Assessments comprised pain measures (Douleur Neuropathique\u20104, McGill Pain Questionnaire, Brief Pain Inventory and Pain Catastrophizing Scale) and maternal well\u2010being measures (Edinburgh Postnatal Depression Scale, Maternal\u2010Foetal Attachment Scale and Prenatal Psychosocial Profile). Women with DNPAP were compared with those without chronic pain to identify associated factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      <jats:italic>De novo<\/jats:italic>\n                      pain was reported by 20.7% of participants, with 59.6% describing it as moderate to severe. DNPAP was significantly associated with higher depressive symptoms, lower maternal\u2010foetal attachment and a history of dysmenorrhea. Mediation analyses identified depressive symptoms as a key factor linking foetal malformations and gestational diseases to\n                      <jats:italic>de novo<\/jats:italic>\n                      pain.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Depression, reduced maternal\u2010foetal attachment and a history of dysmenorrhea were significantly associated with\n                      <jats:italic>de novo<\/jats:italic>\n                      pain during pregnancy. Depressive symptom severity mediated the relationship between foetal malformations or gestational diseases and DNPAP. Clear characterization of pregnancy\u2010related pain can inform preventive and therapeutic strategies to improve maternal health outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance Statement<\/jats:title>\n                    <jats:p>\n                      This study is the first to report the prevalence of\n                      <jats:italic>de novo<\/jats:italic>\n                      chronic pain during pregnancy, which was found to be high affecting 20.7% of the pregnant women.\n                      <jats:italic>De novo<\/jats:italic>\n                      chronic pain in pregnancy is directly associated with depressive symptoms and is mediated by depressive symptoms in cases involving foetal malformation diagnosis and the presence of gestational diseases. A history of dysmenorrhea is significantly associated with the development of\n                      <jats:italic>de novo<\/jats:italic>\n                      chronic pain in pregnancy, suggesting potential shared underlying mechanisms that open possibilities for testing new early\u2010detection, therapeutic, and prognostication approaches to pain across women's life\u2010cycle.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejp.70367","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T09:41:44Z","timestamp":1790588504000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<i>De Novo<\/i>\n                    Pain in Pregnancy: The Mediating Roles of Depression and Maternal\u2010Fetal Attachment in\n                    <i>De Novo<\/i>\n                    Chronic Pain"],"prefix":"10.1002","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-3057-0714","authenticated-orcid":false,"given":"Bruna H.","family":"Micheletti","sequence":"first","affiliation":[{"name":"Albert Einstein University  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Tassi","sequence":"additional","affiliation":[{"name":"Gyneacology and Obstetrics Department University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha K.","family":"Millard","sequence":"additional","affiliation":[{"name":"LIM\u201062, Pain Center, Department of Neurology University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duana S.","family":"Jimenez","sequence":"additional","affiliation":[{"name":"Gyneacology and Obstetrics Department University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana M.","family":"Komatsu","sequence":"additional","affiliation":[{"name":"Gyneacology and Obstetrics Department University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tha\u00eds L.","family":"Matuki","sequence":"additional","affiliation":[{"name":"Gyneacology and Obstetrics Department University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Iglesio","sequence":"additional","affiliation":[{"name":"Center for Neuroplasticity and Pain, Department of Health Science and Technology, Faculty of Medicine Aalborg University  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. S.","family":"Arenholt Louise","sequence":"additional","affiliation":[{"name":"Centre for Clinical Research (Aalborg University), North Denmark Regional Hospital  Hj\u00f8rring DK Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter D. 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