{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T07:59:18Z","timestamp":1790150358070,"version":"4.0.1"},"reference-count":79,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100008710","name":"Dementia Australia Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008710","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chronic low back pain (CLBP) is common in older people and contributes to disability, physical inactivity, cognitive deficits and neural alterations that may increase fall risk. We examined associations between multimodal brain measures and daily\u2010life gait quality and other fall risk factors in older people with CLBP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Thirty\u2010three adults aged \u2265\u200950\u2009years with CLBP completed assessments of physical function, physical activity, and executive function. Daily\u2010life gait quality was assessed using a waist\u2010worn accelerometer. Neuroimaging included diffusion MRI, T1\u2010weighted MRI and magnetic resonance electrical properties tomography.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Gait quality was associated with tissue conductivity in bilateral cerebellar white matter, pallidum and thalamus, but not with structural measures. Short Physical Performance Battery (SPPB) score was associated with fibre density in visual and thalamo\u2010occipital tracts, and hippocampal, thalamic and putamen volumes. Walking duration and daily\u2010life gait speed were associated with cerebellar and subcortical volumes and frontal\u2013parietal conductivity. Physical activity was associated with hippocampal, cerebellar, parietal, and frontal conductivity. Inhibitory control was associated with sensorimotor fibre density and medial orbitofrontal conductivity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In older people with CLBP, gait, physical function and executive function are supported by complementary neural networks, with tissue conductivity providing additional insight into real\u2010world gait performance and physical function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance Statement<\/jats:title>\n                    <jats:p>This study highlights brain mechanisms underlying fall risk in older people with chronic low back pain. Tissue conductivity in cerebellar, subcortical and orbitofrontal regions was linked to balance, gait quality and inhibitory control, providing insights beyond structural MRI. Findings suggest that alterations across neural circuits involved in motor control, cognitive processing and physical activity may contribute to mobility decline. Understanding these neural pathways may help guide targeted interventions to improve balance and reduce fall risk in people with chronic low back pain.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejp.70380","type":"journal-article","created":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T06:27:13Z","timestamp":1789194433000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Neural Correlates of Fall Risk in People Aged 50 and Over With Chronic Low Back Pain: A Multimodal\n                    <scp>MRI<\/scp>\n                    Study"],"prefix":"10.1002","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1039-3827","authenticated-orcid":false,"given":"Mahsa","family":"Seydi","sequence":"first","affiliation":[{"name":"School of Population Health University of New South Wales  Kensington New South Wales Australia"},{"name":"Falls, Balance and Injury Research Centre Neuroscience Research Australia  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"Delbaere","sequence":"additional","affiliation":[{"name":"Falls, Balance and Injury Research Centre Neuroscience Research Australia  Sydney New South Wales Australia"},{"name":"School of Health Sciences University of New South Wales  Kensington New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meghan","family":"Ambrens","sequence":"additional","affiliation":[{"name":"School of Population Health University of New South Wales  Kensington New South Wales Australia"},{"name":"Falls, Balance and Injury Research Centre Neuroscience Research Australia  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James K.","family":"Richardson","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline D.","family":"Rae","sequence":"additional","affiliation":[{"name":"Falls, Balance and Injury Research Centre Neuroscience Research Australia  Sydney New South Wales Australia"},{"name":"School of Psychology University of New South Wales  Kensington New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Cao","sequence":"additional","affiliation":[{"name":"Falls, Balance and Injury Research Centre Neuroscience Research Australia  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Perminder S.","family":"Sachdev","sequence":"additional","affiliation":[{"name":"Centre for Healthy Brain Ageing (CHeBA), School of Clinical Medicine, Faculty of Medicine and Health University of New South Wales  Sydney New South Wales Australia"},{"name":"Neuropsychiatric Institute The Prince of Wales Hospital  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise","family":"Lavrencic","sequence":"additional","affiliation":[{"name":"School of Psychology University of New South Wales  Kensington New South Wales Australia"},{"name":"Aboriginal Health &amp; Ageing Program, Neuroscience Research Australia  Randwick New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Green","sequence":"additional","affiliation":[{"name":"Falls, Balance and Injury Research Centre Neuroscience Research Australia  Sydney New South Wales Australia"},{"name":"School of Clinical Medicine University of New South Wales  Kensington New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0902-8440","authenticated-orcid":false,"given":"Kimberley S.","family":"van Schooten","sequence":"additional","affiliation":[{"name":"School of Population Health University of New South Wales  Kensington New South Wales Australia"},{"name":"Falls, Balance and Injury Research Centre Neuroscience Research Australia  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,11]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2541-04.2004"},{"key":"e_1_2_10_3_1","unstructured":"Australian Institute of Health and Welfare (AIHW).2024.\u201cBack Problems.\u201dhttps:\/\/www.aihw.gov.au\/reports\/chronic\u2010musculoskeletal\u2010conditions\/back\u2010problems."},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cobeha.2014.07.006"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2019.05.001"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304\u20103959(02)00157\u20104"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.853787"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1037\/bne0000412"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.2519\/jospt.2019.8489"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gaitpost.2008.04.015"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.3587\u201014.2015"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3743"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijs.12279"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13246-023-01248-1"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13246-024-01484-z"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.6360\u201011.2012"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330\u2010015\u20103932\u20108"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjsm.2009.060350"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0025042"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.16170"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/13854046.2016.1238510"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2665\u20109913(23)00098\u2010x"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph16101835"},{"key":"e_1_2_10_24_1","unstructured":"FreeSurfer.2026.\u201cSynthSeg Wiki.\u201dhttps:\/\/surfer.nmr.mgh.harvard.edu\/fswiki\/SynthSeg."},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD011279.pub3"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/1545968315613448"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/geronj\/49.2.m85"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/63.12.1335"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.16989"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000002681"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12877\u2010020\u20101487\u20102"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198\u2010012\u20101992\u2010z"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2022.07.013"},{"key":"e_1_2_10_34_1","unstructured":"Katscher U. 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