{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T12:46:19Z","timestamp":1792586779129,"version":"4.5.0"},"reference-count":51,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Quantitative sensory testing (QST) interprets somatosensory function against normative data, most commonly from the German Research Network on Neuropathic Pain (DFNS), based on European volunteers. Whether these reference values describe admixed Latin American populations is unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We retrospectively analysed DFNS QST profiles (dorsum of the foot) in 144 healthy Chilean volunteers. We tested sex differences, identified somatosensory phenotypes using unsupervised clustering, examined rating\u2010scale effects on mechanical pain sensitivity (MPS) in an independent group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200921; 0\u2013100 vs. 0\u201310 scale), and established preliminary Chilean QST reference values overall and stratified by age (&lt;\u200940 vs. \u2265\u200940\u2009years).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Detection thresholds were largely normal. The prominent finding was in MPS (mean\n                      <jats:italic>z<\/jats:italic>\n                      \u2009=\u20091.75\u2009\u00b1\u20091.13), with gain\u2010of\u2010function in 48% of volunteers; no other parameter was comparably deviated. This effect was sex\u2010independent and survived multiple\u2010comparison correction (Cohen's\n                      <jats:italic>d<\/jats:italic>\n                      \u2009=\u20091.54). Replacing the pain\u2010rating scale from 0\u2013100 to 0\u201310 did not reduce MPS ratings, which were higher with the 0\u201310 scale under some conditions. The gain\u2010of\u2010function occurred in both age strata (50.0% and 44.6%), and MPS remained unchanged with age.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Healthy Chilean volunteers show markedly increased MPS relative to DFNS data. This phenotype was not explained by the rating scale used and disappeared when assessed against local reference values. These findings suggest population\u2010specific differences in mechanical pain processing or reporting, including possible biological contributions such as Native American ancestry and Neanderthal\u2010introgressed\n                      <jats:italic>SCN9A<\/jats:italic>\n                      variants, and question the use of imported normative data in Latin American subjects.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance Statement<\/jats:title>\n                    <jats:p>Nearly half of healthy Chilean volunteers were classified as mechanically hypersensitive by European QST reference values, but the discrepancy was confined to MPS, the most subjective parameter of the DFNS protocol, which disappeared when local reference values were applied.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejp.70396","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T13:32:15Z","timestamp":1790343135000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Do Latino Populations Have a Distinct Pain Sensitivity? 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