{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T12:46:26Z","timestamp":1792586786343,"version":"4.5.0"},"reference-count":32,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100008445","name":"Parkinsonforeningen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008445","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005860","name":"Helsefonden","doi-asserted-by":"publisher","award":["15\u2010B\u20100179"],"award-info":[{"award-number":["15\u2010B\u20100179"]}],"id":[{"id":"10.13039\/501100005860","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Pain and sensory disturbances are common non\u2010motor symptoms in Parkinson's disease (PD) and can occur early in the disease course, even before starting dopaminergic treatment. However, somatosensory abnormalities in drug\u2010na\u00efve PD remain insufficiently characterized, particularly in the absence of dopaminergic medication effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this cross\u2010sectional study, 35 people with drug\u2010na\u00efve PD (PwP) and 35 individually age\u2010 and sex\u2010matched healthy controls underwent quantitative sensory testing (QST). Testing included brush stimulation to assess dynamic mechanical allodynia (DMA), pinprick stimulation to assess mechanical pain sensitivity\u2014both rated using a numeric rating scale (NRS)\u2014and pressure pain threshold (PPT) measurements. PwP were stratified by daily pain status. Data were analysed using linear mixed\u2010effects models (LMEMs) that accounted for matching and repeated measures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Pinprick stimulation revealed statistically significant mechanical hyperalgesia across all tested body regions in PwP, regardless of pain status, compared with healthy controls. PPT testing demonstrated significantly lower thresholds in PwP across most body regions, indicating early pressure hyperalgesia. In contrast, brush testing did not reveal significant group differences, and only a small proportion of PwP showed signs of DMA. No significant differences were observed between PwP with and without pain, nor between the disease\u2010onset side and the contralateral side.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Drug\u2010na\u00efve PD is characterized by early nociceptive sensory abnormalities, with consistent evidence of mechanical hyperalgesia even in patients without chronic pain. The absence of DMA suggests that nociceptive hypersensitivity may precede alterations in non\u2010nociceptive processing. Nociceptive QST measures may therefore represent indicators of altered sensory processing in early\u2010stage PwP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance Statement<\/jats:title>\n                    <jats:p>This study adds to existing evidence that sensory disturbances, including pain, may be present already in the early, drug\u2010na\u00efve stages of Parkinson's disease. Clinically, these findings highlight the importance of recognizing pain and sensory abnormalities as potential early non\u2010motor features of PD, including before dopaminergic treatment is initiated.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejp.70403","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T09:15:47Z","timestamp":1790154947000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Early Pain and Sensory Dysfunction in Drug\u2010Na\u00efve Parkinson's Disease: Evidence From Quantitative Sensory Testing"],"prefix":"10.1002","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3035-1325","authenticated-orcid":false,"given":"Maria Skallerup","family":"Andersen","sequence":"first","affiliation":[{"name":"Department of Neurology Aalborg University Hospital  Aalborg Denmark"},{"name":"Department of Clinical Medicine Aalborg University  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0497-2440","authenticated-orcid":false,"given":"Lorenz Martin","family":"Oppel","sequence":"additional","affiliation":[{"name":"Department of Neurology Aalborg University Hospital  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4331-4491","authenticated-orcid":false,"given":"Boris","family":"Modrau","sequence":"additional","affiliation":[{"name":"Department of Neurology Aalborg University Hospital  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8895-6194","authenticated-orcid":false,"given":"Kimmo","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of Neurology Aalborg University Hospital  Aalborg Denmark"},{"name":"Department of Clinical Medicine Aalborg University  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4326-2959","authenticated-orcid":false,"given":"Gertrud","family":"Dam\u2010Dalgeir","sequence":"additional","affiliation":[{"name":"FORSA, Forskningens Hus  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0109-3600","authenticated-orcid":false,"given":"Parisa","family":"Gazerani","sequence":"additional","affiliation":[{"name":"Department of Life Sciences and Health, Faculty of Health Sciences Oslo Metropolitan University  Oslo Norway"},{"name":"Department of Health Science and Technology, Faculty of Medicine Aalborg University  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,23]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.17925\/USN.2015.11.01.27"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26281"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(00)00309-8"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12888\u2010015\u20100529\u20103"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415\u2010016\u20108390\u2010y"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20629"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13323"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22716"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000923"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.3233\/JPD\u2010181513"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.17.5.427"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.55.3.181"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072\u2010014\u20101942\u2010y"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870090112"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00482\u2010015\u20100093\u20102"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23825"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2008.145995"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.846"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000002107"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532\u20105415.2005.53221.x"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0164607"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26077"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26424"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/13825585.2019.1577352"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2006.01.041"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2018.06.001"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(25)00033\u2010X"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22932"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfma.2017.04.024"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0136541"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2012.54"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415\u2010010\u20105812\u20100"}],"container-title":["European Journal of Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ejp.70403","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ejp.70403","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ejp.70403","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T12:23:25Z","timestamp":1792585405000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ejp.70403"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,23]]},"references-count":32,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/ejp.70403"],"URL":"https:\/\/doi.org\/10.1002\/ejp.70403","archive":["Portico"],"relation":{},"ISSN":["1090-3801","1532-2149"],"issn-type":[{"value":"1090-3801","type":"print"},{"value":"1532-2149","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,23]]},"assertion":[{"value":"2026-03-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70403"}}