{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T12:46:30Z","timestamp":1792586790943,"version":"4.5.0"},"reference-count":48,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Auditory input is known to modulate the perception of pain, yet the reciprocal influence, how pain affects auditory processing, remains less well understood. We investigated how continuous tonic pain dynamically alters auditory cortical responses in humans.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using a three\u2010stimulus auditory oddball paradigm combined with EEG, we recorded event\u2010related potentials (ERPs) while participants experienced thermal stimulation under three conditions: baseline, non\u2010painful warmth, and pain. We examined multiple stages of auditory processing, including early sensory encoding (N1, P2), automatic deviance detection (MMN), and attentional reorienting (P3a).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Tonic pain modulated auditory ERPs in a stage\u2010 and component\u2010specific manner. Compared to baseline and warm conditions, pain was associated with enhanced P2 responses to distractors and reduced MMN and P3a amplitudes, although no statistically significant differences in behavioural performance were observed. This pattern suggests enhanced early salience detection alongside reduced pre\u2010attentive deviance detection and involuntary attentional shifts under pain. The warm condition selectively modulated N1 amplitude, indicating that some effects may be related to the affective and attentional demands of pain rather than somatosensory stimulation per se.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Continuous tonic pain is associated with selective modulation of auditory processing, characterized by enhanced early sensory responsiveness and reduced higher\u2010order attentional engagement. This biphasic neural pattern, observed in the absence of measurable behavioural differences, is consistent with predictive coding and salience network accounts of pain\u2010attention interactions and highlights the sensitivity of ERPs for detecting pain\u2010related neural reweighting. The absence of statistically significant behavioural effects should be interpreted with caution and may reflect relatively subtle or context\u2010dependent influences of pain under the present task conditions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance Statement<\/jats:title>\n                    <jats:p>This study is among the first to systematically examine how experimentally induced tonic pain modulates distinct stages of auditory processing in healthy individuals using high\u2010resolution ERPs, with a task design and hypothesis framework capable of teasing apart the cognitive mechanisms underlying these changes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejp.70405","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T14:41:54Z","timestamp":1791556914000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pain Enhances the Auditory\n                    <scp>P2<\/scp>\n                    but Attenuates Mismatch Response and P3a"],"prefix":"10.1002","volume":"30","author":[{"given":"Alexandre","family":"Lehmann","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Head &amp; Neck Surgery McGill University  Montreal Quebec Canada"},{"name":"International Laboratory for Brain, Music and Sound Research (BRAMS)  Montreal Quebec Canada"},{"name":"Center for Research on Brain, Language and Music (CRBLM)  Montreal Quebec Canada"},{"name":"Department of Psychology University of Montreal  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Sch\u00f6nwiesner","sequence":"additional","affiliation":[{"name":"International Laboratory for Brain, Music and Sound Research (BRAMS)  Montreal Quebec Canada"},{"name":"Center for Research on Brain, Language and Music (CRBLM)  Montreal Quebec Canada"},{"name":"Department of Psychology University of Montreal  Montreal Quebec Canada"},{"name":"Centre de Recherche en Neuropsychologie et Cognition University of Montreal  Montreal Quebec Canada"},{"name":"Institute of Biology Leipzig University  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Rainville","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Montreal  Montreal Quebec Canada"},{"name":"Centre de Recherche en Neuropsychologie et Cognition University of Montreal  Montreal Quebec Canada"},{"name":"D\u00e9partement de Stomatologie Universit\u00e9 de Montr\u00e9al  Montr\u00e9al Quebec Canada"},{"name":"Centre de Recherche de L'institut Universitaire de G\u00e9riatrie de Montr\u00e9al  Montr\u00e9al Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40359-024-01601-3"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2024.120711"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0040215"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2014.10.012"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-5597(98)00033-1"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn755"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2003.10.009"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/eujp.2001.0342"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1027\/0269-8803.20.1.21"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/72991"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1037\/0033-2909.125.3.356"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsycho.2010.07.010"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-34099-y"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00406-023-01709-4"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2008.11.029"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2017.12.012"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2017.07.061"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2019.116432"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1162\/jocn_a_02336"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpsycho.2003.08.001"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-010-2340-1"},{"key":"e_1_2_10_23_1","unstructured":"Kawahara H. 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