{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T07:40:56Z","timestamp":1792568456068,"version":"4.5.0"},"reference-count":35,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Postherpetic neuralgia (PHN) is a chronic neuropathic pain condition associated with central nervous system reorganization, but hypothalamic alterations remain poorly understood. We investigated hypothalamic subfield volumes and morphometric covariance network organization in patients with PHN.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective cross\u2010sectional study included 42 patients with PHN and 41 healthy controls whose hypothalamic subfield volumes were obtained from T1\u2010weighted MRI using automated FreeSurfer segmentation. Bilateral mean raw subfield volumes were compared between groups using analysis of covariance, adjusting for age, sex and estimated total intracranial volume, with false discovery rate correction for multiple comparisons. Morphometric covariance networks were constructed from age\u2010 and sex\u2010residualized subfield volumes and graph\u2010theoretical measures were compared using permutation testing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After adjustment for estimated total intracranial volume, age and sex, the tubular superior subfield was nominally larger in PHN (adjusted difference, 4.95\u2009mm\n                      <jats:sup>3<\/jats:sup>\n                      ; 95% CI, 0.05\u20139.85;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.048), but did not survive FDR correction. No other subfield or whole\u2010hypothalamic volume differed significantly. PHN showed reduced local efficiency and clustering coefficient and increased characteristic path length, without a significant difference in global efficiency. No pain\u2010side\u2010dependent lateralization or significant associations between subfield volumes and pain measures or disease duration were observed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>PHN was associated with altered hypothalamic morphometric covariance organization, characterized by reduced local network segregation and increased characteristic path length, while regional volume differences were limited after intracranial volume correction. These findings suggest that PHN\u2010related central reorganization may involve hypothalamic systems related to homeostatic regulation and stress adaptation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance Statement<\/jats:title>\n                    <jats:p>This study demonstrates altered morphometric covariance organization of hypothalamic subfields in postherpetic neuralgia, despite limited evidence of regional volumetric differences after intracranial volume adjustment. These findings suggest that hypothalamic involvement in PHN may be better reflected by altered coordinated structural organization than by regional volume changes alone.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejp.70434","type":"journal-article","created":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T07:03:51Z","timestamp":1792566231000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Structural Reorganization of Hypothalamic Subfields in Postherpetic Neuralgia: Volumetric and Morphometric Covariance Network Analyses"],"prefix":"10.1002","volume":"30","author":[{"given":"Daeseok","family":"Oh","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Haeundae Paik Hospital Inje University College of Medicine  Busan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Ah","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neurology, Haeundae Paik Hospital Inje University College of Medicine  Busan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ho\u2010Joon","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Radiology, Haeundae Paik Hospital Inje University College of Medicine  Busan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4229-7741","authenticated-orcid":false,"given":"Kang Min","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Neurology, Haeundae Paik Hospital Inje University College of Medicine  Busan Republic of 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