{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T06:32:45Z","timestamp":1790404365747,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,4,21]],"date-time":"2015-04-21T00:00:00Z","timestamp":1429574400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Auvergne University"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Dopamine is implicated in different orofacial pain\u2010related diseases. The mechanisms underlying this invalidating pain are not yet understood. Therefore, the present study investigated if unilateral or bilateral lesions of the medial forebrain bundle (<jats:styled-content style=\"fixed-case\">MFB<\/jats:styled-content>) could induce a trigeminal static mechanical allodynia (<jats:styled-content style=\"fixed-case\">SMA<\/jats:styled-content>) comparable to that obtained after chronic construction injury of the infraorbital nerve (<jats:styled-content style=\"fixed-case\">CCI<\/jats:styled-content>\u2010IoN) in rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Unilateral and bilateral nigrostriatal lesions were obtained by injecting 6\u2010hydroxydopamine into the <jats:styled-content style=\"fixed-case\">MFB<\/jats:styled-content>, and peripheral lesion was obtained by <jats:styled-content style=\"fixed-case\">CCI<\/jats:styled-content>\u2010IoN. Static allodynia behaviour was tested by a mild non\u2010noxious static von Frey filament stimulus. The analgesic effects of bromocriptine (D2R agonist) were assessed by both intraperitoneal and intracisternal injections. Finally, immunohistochemical study was done to investigate the implication of the protein kinase c isoform gamma (<jats:styled-content style=\"fixed-case\">PKC<\/jats:styled-content>\u03b3) and the phosphorylated form of extracellular signal\u2010related kinase 1\/2 (<jats:styled-content style=\"fixed-case\">pERK<\/jats:styled-content>1\/2) in pain sensitization at segmental level.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>6\u2010<jats:styled-content style=\"fixed-case\">OHDA<\/jats:styled-content>\u2010lesioned animals developed <jats:styled-content style=\"fixed-case\">SMA<\/jats:styled-content> in the orofacial region as assessed by non\u2010noxious stimuli. Intraperitoneal and intracisternal injections of bromocriptine alleviated this allodynic behaviour. Investigations within the medullary dorsal horn revealed an increase in <jats:styled-content style=\"fixed-case\">PKC<\/jats:styled-content>\u03b3 expression, a protein implicated in the chronicity of pain, within superficial laminae in 6\u2010<jats:styled-content style=\"fixed-case\">OHDA<\/jats:styled-content>\u2010lesioned rats. Also static mechanical stimulations of the orofacial region evoked increased expression of the molecular pain marker <jats:styled-content style=\"fixed-case\">pERK<\/jats:styled-content>1\/2 in 6\u2010<jats:styled-content style=\"fixed-case\">OHDA<\/jats:styled-content>\u2010lesioned rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our data show that unilateral and bilateral dopamine depletion promoted trigeminal <jats:styled-content style=\"fixed-case\">SMA<\/jats:styled-content> comparable to that obtained after <jats:styled-content style=\"fixed-case\">CCI<\/jats:styled-content>\u2010IoN. This allodynia can be alleviated by D2R activation, making D2R agonist a potential analgesic for orofacial neuropathic pain.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ejp.707","type":"journal-article","created":{"date-parts":[[2015,4,21]],"date-time":"2015-04-21T10:13:38Z","timestamp":1429611218000},"page":"196-205","source":"Crossref","is-referenced-by-count":22,"title":["Nigrostriatal dopaminergic depletion produces orofacial static mechanical allodynia"],"prefix":"10.1002","volume":"20","author":[{"given":"W.","family":"Dieb","sequence":"first","affiliation":[{"name":"Clermont Universit\u00e9 EA7280 Neuro\u2010psycho\u2010pharmacologie des syst\u00e8mes dopaminergiques sous\u2010corticaux Universit\u00e9 d'Auvergne Clermont\u2010Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Ouachikh","sequence":"additional","affiliation":[{"name":"Clermont Universit\u00e9 EA7280 Neuro\u2010psycho\u2010pharmacologie des syst\u00e8mes dopaminergiques sous\u2010corticaux Universit\u00e9 d'Auvergne Clermont\u2010Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Durif","sequence":"additional","affiliation":[{"name":"Clermont Universit\u00e9 EA7280 Neuro\u2010psycho\u2010pharmacologie des syst\u00e8mes dopaminergiques sous\u2010corticaux Universit\u00e9 d'Auvergne Clermont\u2010Ferrand France"},{"name":"Service de Neurologie CHU Clermont\u2010Ferrand  France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Hafidi","sequence":"additional","affiliation":[{"name":"Clermont Universit\u00e9 EA7280 Neuro\u2010psycho\u2010pharmacologie des syst\u00e8mes dopaminergiques sous\u2010corticaux Universit\u00e9 d'Auvergne Clermont\u2010Ferrand 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