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It remains undetermined whether pain occurs secondary to motor impairment and to which extent it can be relieved by improvement of motor symptoms. The aim of this review was to examine the current knowledge on the mechanisms behind sensory changes and pain in<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>and to assess the modulatory effects of motor treatment on these sensory abnormalities. A comprehensive literature search was performed. We selected studies investigating sensory changes and pain in<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>and the effects of levodopa administration and deep brain stimulation (<jats:styled-content style=\"fixed-case\">DBS<\/jats:styled-content>) on these symptoms.<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>patients have altered sensory and pain thresholds in the off\u2010medication state. Both levodopa and<jats:styled-content style=\"fixed-case\">DBS<\/jats:styled-content>improve motor symptoms (i.e.: bradykinesia, tremor) and change sensory abnormalities towards normal levels. However, there is no direct correlation between sensory\/pain changes and motor improvement, suggesting that motor and non\u2010motor symptoms do not necessarily share the same mechanisms. Whether dopamine and<jats:styled-content style=\"fixed-case\">DBS<\/jats:styled-content>have a real antinociceptive effect or simply a modulatory effect in pain perception remain uncertain. These data may provide useful insights into a mechanism\u2010based approach to pain in<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>, pointing out the role of the dopaminergic system in pain perception and the importance of the characterization of different pain syndromes related to<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>before specific treatment can be instituted.<\/jats:p>","DOI":"10.1002\/ejp.745","type":"journal-article","created":{"date-parts":[[2015,7,6]],"date-time":"2015-07-06T06:48:52Z","timestamp":1436165332000},"page":"151-165","source":"Crossref","is-referenced-by-count":86,"title":["Sensory abnormalities and pain in Parkinson disease and its modulation by treatment of motor symptoms"],"prefix":"10.1002","volume":"20","author":[{"given":"R.G.","family":"Cury","sequence":"first","affiliation":[{"name":"Pain Center Department of Neurology University of S\u00e3o Paulo S\u00e3o Paulo Brazil"},{"name":"Pain Center Instituto do 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