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Tapentadol is a recently discovered analgesic possessing \u03bc\u2010opioid receptor agonism and noradrenaline re\u2010uptake inhibition in a single molecule. Taking into consideration, the pharmacological similarities between opioids and cannabinoids, we assumed that combination of cannabinoids with noradrenaline re\u2010uptake inhibitors might also be effective. We therefore aimed to determine whether combining 1:1, 1:3 and 3:1 fixed ratios of the synthetic cannabinoid<jats:styled-content style=\"fixed-case\">WIN<\/jats:styled-content>55,212\u20102 and the selective noradrenaline re\u2010uptake inhibitor maprotiline exert anti\u2010allodynic synergy on nerve\u2010injured neuropathic mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Partial tight ligation of the sciatic nerve was made in mice; on pre\u2010operative and post\u2010operative 15 days basal mechanical allodynia, cold allodynia and motor function were assessed using von Frey filaments, hot\/cold plate and rota rod apparatus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mechanical and cold allodynia developed in all groups on post\u2010operative 15 days. Development of cold allodynia was statistically significant in all groups (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05); therefore, cold allodynia was used in combination studies. As shown by isobolographic analysis, interactions of 1:1 and 3:1 ratios of<jats:styled-content style=\"fixed-case\">WIN<\/jats:styled-content>55,212\u20102:maprotiline combinations were supra\u2010additive, whereas 1:3 ratio was sub\u2010additive.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Overall, our data suggest that combination of a cannabinoid with a selective noradrenaline re\u2010uptake inhibitor may offer a beneficial treatment option for neuropathic pain.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ejp.752","type":"journal-article","created":{"date-parts":[[2015,7,24]],"date-time":"2015-07-24T06:29:34Z","timestamp":1437719374000},"page":"465-471","source":"Crossref","is-referenced-by-count":8,"title":["Analysis of the anti\u2010allodynic effects of combination of a synthetic cannabinoid and a selective noradrenaline re\u2010uptake inhibitor in nerve injury\u2010induced neuropathic 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