{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:37:02Z","timestamp":1787319422689,"version":"build-2736575974"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,9,28]],"date-time":"2015-09-28T00:00:00Z","timestamp":1443398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2016,1]]},"abstract":"Abstract<\/jats:title>\n \n Prurigo nodularis (\n PN<\/jats:styled-content>\n ) is characterized by multiple hyperkeratotic nodules, papules and the presence of intensive pruritus. This leads to an impaired quality of life and high burden due not only to the severe itch but also the chronic, skin lesions and lack of treatment options.\n <\/jats:p>\n \n The pathogenesis of\n PN<\/jats:styled-content>\n is not completely clarified. Previous studies have demonstrated just how important the interaction between cutaneous nerve fibres and immune cells is. Besides a reduced intraepidermal nerve fibre density, there are increased dermal levels of neuropeptides such as substance P, calcitonin gene\u2010related peptide and nerve growth factor, as well as a predominant presence of eosinophils and mast cells. An interaction of these factors results in a complex relationship which will be discussed in this article.\n <\/jats:p>","DOI":"10.1002\/ejp.767","type":"journal-article","created":{"date-parts":[[2015,9,28]],"date-time":"2015-09-28T22:11:34Z","timestamp":1443478294000},"page":"37-40","source":"Crossref","is-referenced-by-count":79,"title":["The pathogenesis of Prurigo nodularis \u2013 \u2018Super\u2010Itch\u2019 in exploration"],"prefix":"10.1002","volume":"20","author":[{"given":"C.","family":"Zeidler","sequence":"first","affiliation":[{"name":"Department of Dermatology Center for Chronic Pruritus University Hospital of M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"St\u00e4nder","sequence":"additional","affiliation":[{"name":"Department of Dermatology Center for Chronic Pruritus University Hospital of M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,9,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0009922808321899"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12222"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/09546634.2013.814759"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2004.12.019"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2010.03.020"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2012.04481.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-001-0285-8"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.6.2214"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.1998.tb01718.x"},{"key":"e_1_2_8_11_1","first-page":"297","article-title":"Dendritic mast cells in prurigo nodularis skin","volume":"9","author":"Liang Y.","year":"1999","journal-title":"Eur J Dermatol"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0560.2000.027007359.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2015.02.021"},{"key":"e_1_2_8_14_1","first-page":"897","article-title":"Le neurome de la lichenification circonscrite nodulaire chronique (lichen ruber obtusus corne prurigo nodularis)","volume":"7","author":"Pautrier L.M.","year":"1934","journal-title":"Annales de Dermatologic Syph"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00105-006-1125-8"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.05.047"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10306.x"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.10.033"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0010968"},{"key":"e_1_2_8_20_1","first-page":"93","article-title":"Competence Center Chronic Pruritus at the University Hospital of M\u00fcnster: A Dedicated Center with a Decade of Experience in Multidisciplinary Medical Care","volume":"634","author":"St\u00e4nder S.","year":"2013","journal-title":"Acta Dermatol Venereol"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2009.01484.x"}],"container-title":["European Journal of Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fejp.767","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ejp.767","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T02:39:58Z","timestamp":1696300798000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ejp.767"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,28]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["10.1002\/ejp.767"],"URL":"https:\/\/doi.org\/10.1002\/ejp.767","archive":["Portico"],"relation":{},"ISSN":["1090-3801","1532-2149"],"issn-type":[{"value":"1090-3801","type":"print"},{"value":"1532-2149","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,28]]}}}