{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T04:34:43Z","timestamp":1788582883591,"version":"build-2803163510"},"reference-count":44,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,9,22]],"date-time":"2015-09-22T00:00:00Z","timestamp":1442880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Pain catastrophizing significantly affects an individual's experience of pain. High pain catastrophizing is associated with increased fear avoidance behaviours, pain intensity and disability. The aim of this investigation was to determine the effect of pain catastrophizing on ongoing brain activity and movement\u2010evoked brain activity during acute orofacial muscle pain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010four healthy, pain\u2010free subjects were recruited. In 17 subjects, the effect of catastrophizing on regional brain activity was determined. In 19 subjects, functional magnetic resonance imaging was used to determine the effects of pain catastrophizing on brain activation patterns during jaw movements in the presence of ongoing pain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found that in the presence of pain, catastrophizing was significantly correlated with activity in multi\u2010sensory integrative brain regions, including the dorsolateral and medial prefrontal cortices. Importantly, this relationship did not exist when subjects were not experiencing pain. In addition, during repetitive open\u2013close jaw movements in the presence of pain, activity in the primary motor cortex, cerebellar cortex and the trigeminal motor nucleus was positively correlated with pain catastrophizing scores. In contrast, in the dorsolateral prefrontal cortex, as pain catastrophizing scores increased, the magnitude of signal intensity change during jaw movements decreased. Again, no such relationships occurred when the individual was not in pain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These data show that during pain, catastrophic thinking has a significant impact on activity in motor and sensory integrative regions. Reducing negative coping strategies may be an effective means in reducing fear avoidance behaviours and the intensity of ongoing pain.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ejp.781","type":"journal-article","created":{"date-parts":[[2015,9,22]],"date-time":"2015-09-22T04:54:59Z","timestamp":1442897699000},"page":"639-651","source":"Crossref","is-referenced-by-count":29,"title":["The effects of catastrophizing on central motor activity"],"prefix":"10.1002","volume":"20","author":[{"given":"L.A.","family":"Henderson","sequence":"first","affiliation":[{"name":"Department of Anatomy and Histology University of Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Akhter","sequence":"additional","affiliation":[{"name":"Jaw Function and Orofacial Pain Research Unit Faculty of Dentistry Westmead Hospital University of Sydney Australia"},{"name":"School of Dentistry and Health Sciences Charles Sturt University Orange Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.M.","family":"Youssef","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Histology University of Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.M.","family":"Reeves","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Histology University of Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.C.","family":"Peck","sequence":"additional","affiliation":[{"name":"Jaw Function and Orofacial Pain Research Unit Faculty of Dentistry Westmead Hospital University of Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.M.","family":"Murray","sequence":"additional","affiliation":[{"name":"Jaw Function and Orofacial Pain Research Unit Faculty of Dentistry Westmead Hospital University of Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Svensson","sequence":"additional","affiliation":[{"name":"Section\u00a0of Clinical Oral Physiology School of Dentistry Aarhus University Denmark"},{"name":"MindLab Centre for Functionally Integrative Neuroscience (CFIN) Aarhus University Hospital Denmark"},{"name":"Department of Oral Maxillofacial Surgery Aarhus University Hospital Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,9,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.2174\/156720111796642327"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.11607\/ofph.1211"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004356-200306000-00004"},{"key":"e_1_2_7_5_1","first-page":"757","article-title":"A new learning algorithm for blind signal separation","volume":"8","author":"Amari S.","year":"1996","journal-title":"Adv Neur In"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2004.08.008"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.1048"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2013.08.015"},{"key":"e_1_2_7_9_1","volume-title":"Applied Multiple Regression\/Correlation Analysis for the Behavioral Sciences","author":"Cohen J.","year":"1983"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(03)00123-1"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn0709-821"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.460020402"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002508-200403000-00001"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brat.2004.10.006"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh098"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cogbrainres.2005.05.002"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.280.2.147"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2010.10.020"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.27649"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.39043"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2321"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10865-006-9085-0"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpain.2006.02.009"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awg102"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1139\/y91-102"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2003.12.042"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ajp.0000131414.84596.99"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7044.120.2.474"},{"key":"e_1_2_7_29_1","first-page":"263","article-title":"Orofacial pain and jaw muscle activity: A new model","volume":"21","author":"Murray G.M.","year":"2007","journal-title":"J Orofac Pain"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2012.04.009"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1532-2149.2011.00105.x"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002508-200501000-00010"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1834-7819.2008.00050.x"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1586\/ern.09.34"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2005.11.008"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002508-200106000-00009"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1037\/1040-3590.7.4.524"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002508-200103000-00008"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(95)00133-6"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/PL00005738"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0b013e3181657f1a"},{"key":"e_1_2_7_42_1","first-page":"291","article-title":"Catastrophizing is associated with clinical examination findings, activity interference, and health care use among patients with temporomandibular disorders","volume":"19","author":"Turner J.A.","year":"2005","journal-title":"J Orofac Pain"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2011.07.004"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2568-06.2006"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.12.058"}],"container-title":["European Journal of Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fejp.781","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ejp.781","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T09:58:04Z","timestamp":1753351084000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ejp.781"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,22]]},"references-count":44,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["10.1002\/ejp.781"],"URL":"https:\/\/doi.org\/10.1002\/ejp.781","archive":["Portico"],"relation":{},"ISSN":["1090-3801","1532-2149"],"issn-type":[{"value":"1090-3801","type":"print"},{"value":"1532-2149","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,22]]}}}