{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:12:08Z","timestamp":1787235128014,"version":"build-2736575974"},"reference-count":56,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,12,18]],"date-time":"2015-12-18T00:00:00Z","timestamp":1450396800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chronic pelvic pain (CPP) is a high burden for patients and society. It affects 15\u201324% of women in reproductive age and is an area of high unmet medical need. CPP can be caused by a wide range of visceral diseases such as abdominal infections, gastrointestinal or gynaecological diseases like endometriosis. Despite the high medical need for this condition, pharmacological approaches are hampered by the limited number of available methods for the behavioural evaluation of pain in inflammation\u2010driven animal models of pelvic pain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The dynamic weight bearing (DWB) system was used for the evaluation of spontaneous behaviour changes in the zymosan\u2010induced peritonitis mouse model. Inflammatory mediator levels were evaluated in peritoneal lavage and their correlation with the behavioural endpoints was assessed. We evaluated the effect on behavioural endpoints of the selective cyclooxygenase\u20102 (COX\u20102) inhibitor celecoxib and the Na\n                      <jats:sub>v<\/jats:sub>\n                      1.8 blocker A\u2010803467.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The presence of a relief posture, characterized by a significantly increased weight distribution towards the front paws, was observed following intraperitoneal injection of zymosan. A positive correlation was detected between\n                      <jats:styled-content style=\"fixed-case\">PGE<\/jats:styled-content>\n                      2 levels in the peritoneal lavage and\n                      <jats:styled-content style=\"fixed-case\">DWB<\/jats:styled-content>\n                      endpoints. In addition, zymosan\u2010induced weight bearing changes were reverted by celecoxib and A\u2010803467.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study described for the first time the use of DWB as a non\u2010subjective and non\u2010reflexive method for the evaluation of inflammatory\u2010driven abdominal pain in a mouse model.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejp.800","type":"journal-article","created":{"date-parts":[[2015,12,18]],"date-time":"2015-12-18T20:13:31Z","timestamp":1450469611000},"page":"742-752","source":"Crossref","is-referenced-by-count":26,"title":["Dynamic weight bearing as a non\u2010reflexive method for the measurement of abdominal pain in mice"],"prefix":"10.1002","volume":"20","author":[{"given":"A.","family":"Laux\u2010Biehlmann","sequence":"first","affiliation":[{"name":"Global Drug Discovery 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