{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T18:50:35Z","timestamp":1790362235902,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,10,30]],"date-time":"2015-10-30T00:00:00Z","timestamp":1446163200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Despite the development of multimodal analgesia for postoperative pain management, opioids are still required for effective pain relief after knee arthroplasty. We aimed to identify the determinants of post\u2010operative pain intensity and post\u2010operative opioid requirement in this context.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this observational prospective study, we recorded patient characteristics, pre\u2010operative pain intensity, anxiety and depression levels, sensitivity and pain thresholds in response to an electrical stimulus, and mu\u2010opioid receptor (<jats:styled-content style=\"fixed-case\">OPRM<\/jats:styled-content>1) and catechol\u2010O\u2010methyltransferase (<jats:styled-content style=\"fixed-case\">COMT<\/jats:styled-content>) single\u2010nucleotide polymorphisms. Multivariate linear regression models were used to identify predictors of post\u2010operative pain at rest and opioid requirement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 109 patients. Pre\u2010operative pain at rest (<jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.047), anxiety level (<jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.001) and neuropathic pain symptoms (<jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.030) were independently and positively associated with mean post\u2010operative pain intensity adjusted for mean post\u2010operative morphine equivalent dose (<jats:styled-content style=\"fixed-case\">MED<\/jats:styled-content>). Mean post\u2010operative pain intensity at rest was lower (<jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.006) in patients receiving celecoxib and pregabalin in the post\u2010operative period, with all other variables constant. Mean post\u2010operative <jats:styled-content style=\"fixed-case\">MED<\/jats:styled-content> over 5\u00a0days was low, but highly variable (78.2\u00a0\u00b1\u00a032.1\u00a0mg, from 9.9 to 170\u00a0mg). Following adjustment for mean post\u2010operative pain intensity, it was independently negatively correlated with age (<jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.004), and positively correlated with associated paracetamol treatment (<jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.031). No genetic effect was detected in our sample.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings suggest that clinicians could use the pre\u2010operative pain profile, in terms of anxiety levels, neuropathic pain symptoms, and chronic pre\u2010operative pain intensity, to improve the efficacy of pain management after knee surgery.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ejp.808","type":"journal-article","created":{"date-parts":[[2015,10,30]],"date-time":"2015-10-30T14:33:21Z","timestamp":1446215601000},"page":"822-832","source":"Crossref","is-referenced-by-count":80,"title":["Acute pain Factors predictive of post\u2010operative pain and opioid requirement in multimodal analgesia following knee replacement"],"prefix":"10.1002","volume":"20","author":[{"given":"J.","family":"Thomazeau","sequence":"first","affiliation":[{"name":"INSERM 987 Physiopathologie et pharmacologie clinique de la douleur Ambroise Par\u00e9 Paris France"},{"name":"Assistance 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