{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T22:32:38Z","timestamp":1759617158371},"reference-count":63,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,12,21]],"date-time":"2015-12-21T00:00:00Z","timestamp":1450656000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008102","name":"University of Cincinnati","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008102","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NS55860"],"award-info":[{"award-number":["NS55860"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81372808","81173614"],"award-info":[{"award-number":["81372808","81173614"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Endometriosis is a common cause of pain including radicular pain. Ectopic endometrial tissue may directly affect peripheral nerves including the sciatic, which has not been modelled in animals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We developed a rat model for sciatic endometriosis by grafting a piece of autologous uterine tissue around the sciatic nerve. Control animals underwent a similar surgery but received a graft of pelvic fat tissue.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The uterine grafts survived and developed fluid\u2010filled cysts; the adjacent nerve showed signs of swelling and damage. Mechanical and cold hypersensitivity and allodynia of the ipsilateral hindpaw developed gradually over the first 2\u00a0weeks after the surgery, peaked at 2\u20135\u00a0weeks, and was almost resolved by 7\u00a0weeks. Control animals showed only minor changes in these pain behaviours. Histological signs of inflammation in the uterine graft and in the adjacent nerve were observed at 3\u00a0weeks but were resolving by 7\u00a0weeks. <jats:italic>In vivo<\/jats:italic> fibre recording showed increased spontaneous activity, especially of C\u2010fibres, in sciatic nerve proximal to the uterine graft. Several pro\u2010inflammatory cytokines including interluekin\u201018, <jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content>, fractalkine, and <jats:styled-content style=\"fixed-case\">MIP<\/jats:styled-content>\u20101\u03b1, were elevated in the uterine graft plus sciatic nerve samples, compared to samples from normal nerve or nerve plus fat graft. Growth associated protein 43 (<jats:styled-content style=\"fixed-case\">GAP<\/jats:styled-content>43), a marker of regenerating nerve fibres, was observed in the adjacent sciatic nerve as well as in the uterine graft.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This model shared many features with other rat models of endometriosis, but also had some unique features more closely related to neuropathic pain models.<\/jats:p><\/jats:sec><jats:sec><jats:title>What does this study\/review add<\/jats:title><jats:p>Some especially painful forms of endometriosis are essentially neuropathic, because peripheral nerves are directly affected by nearby ectopic endometrial tissue. We modelled endometriosis by implanting autologous uterine tissue around rat sciatic nerve. We observed mechanical and cold pain behaviours along with signs of inflammation and nerve damage and increased pro\u2010inflammatory cytokines at the implant site. Pain behaviours correlated with signs of nerve inflammation and damage rather than with cyst survival.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ejp.827","type":"journal-article","created":{"date-parts":[[2015,12,21]],"date-time":"2015-12-21T12:52:47Z","timestamp":1450702367000},"page":"1044-1057","source":"Crossref","is-referenced-by-count":14,"title":["Sciatic endometriosis induces mechanical hypersensitivity, segmental nerve damage, and robust local inflammation in rats"],"prefix":"10.1002","volume":"20","author":[{"given":"S.","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Qilu Hospital Shandong University Jinan China"},{"name":"Pain Research Center Department of Anesthesiology University of Cincinnati College of Medicine Cincinnati OH 45267 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Xie","sequence":"additional","affiliation":[{"name":"Pain Research Center Department of Anesthesiology University of Cincinnati College of Medicine Cincinnati OH 45267 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.A.","family":"Strong","sequence":"additional","affiliation":[{"name":"Pain Research Center Department of Anesthesiology University of Cincinnati College of Medicine Cincinnati OH 45267 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Qilu Hospital Shandong University Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.\u2010M.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Pain Research Center Department of Anesthesiology University of Cincinnati College of Medicine Cincinnati OH 45267 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,12,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2012.08.033"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2013.11.008"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.527"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/15.8.1744"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deh150"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1966.25.6.0652"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(01)01906-1"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1111445"},{"key":"e_1_2_6_10_1","unstructured":"Bove G.M. 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