{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T15:30:10Z","timestamp":1778859010192,"version":"3.51.4"},"reference-count":38,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,2,5]],"date-time":"2016-02-05T00:00:00Z","timestamp":1454630400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Chonnam National University Hospital Biomedical Research Institute","award":["CRI 14033-1"],"award-info":[{"award-number":["CRI 14033-1"]}]},{"name":"Chonnam National University Hospital Biomedical Research Institute","award":["BCRI 14001-55"],"award-info":[{"award-number":["BCRI 14001-55"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2016,8]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Although polymorphisms of the catechol\u2010O\u2010methyl transferase (COMT<\/jats:styled-content>) gene have been implicated in altered pain sensitivity, results concerning the association between COMT<\/jats:styled-content> gene polymorphisms and fibromyalgia (FM<\/jats:styled-content>) are equivocal. We assessed the associations between COMT<\/jats:styled-content> single\u2010nucleotide polymorphisms (SNP<\/jats:styled-content>) and FM<\/jats:styled-content> risk and symptom severity.<\/jats:p><\/jats:sec>Methods<\/jats:title>In total, 409 FM<\/jats:styled-content> patients and 423 controls were enrolled. Alleles and genotypes at five positions [rs6269 (A>G), rs4633 (C>T), rs4818 (C>G), rs4680 (C>G) and rs165599 (A>G)] in the COMT<\/jats:styled-content> gene were genotyped from peripheral blood DNA<\/jats:styled-content>.<\/jats:p><\/jats:sec>Results<\/jats:title>Alleles and genotypes of the rs4818 COMT<\/jats:styled-content> gene polymorphism were significantly associated with increased susceptibility to FM<\/jats:styled-content>. The rs4818 GG<\/jats:styled-content> genotype was more strongly associated with FM<\/jats:styled-content> compared to the CC<\/jats:styled-content> genotype (OR<\/jats:styled-content>\u00a0=\u00a01.680, 95% CI<\/jats:styled-content>: 1.057, 2.672, p\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.027). Although allele and genotype frequencies did not differ among groups, the rs4633 CT<\/jats:styled-content> genotype was not associated with the presence of FM<\/jats:styled-content> following adjustment for age and sex (OR<\/jats:styled-content>\u00a0=\u00a00.745; 95% CI<\/jats:styled-content>: 0.558, 0.995; p\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.046). However, no association was observed between clinical measures and individual COMT SNP<\/jats:styled-content>s. In haplotype analysis, there was a significant association between ACG<\/jats:styled-content> haplotype and FM<\/jats:styled-content> susceptibility sex (OR<\/jats:styled-content>\u00a0=\u00a02.960, 95% CI<\/jats:styled-content>: 1.447, 6.056, p\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.003) and the number of tender points (p\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.046).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>This large\u2010scale study suggests that polymorphisms of the COMT<\/jats:styled-content> gene may be associated with FM<\/jats:styled-content> risk and pain sensitivity in\u00a0Korean FM<\/jats:styled-content> patients. However, our results differed to those of previous studies, suggesting ethnic variation in COMT<\/jats:styled-content> gene polymorphisms in FM<\/jats:styled-content>.<\/jats:p><\/jats:sec>What does this study add<\/jats:title>By contrast to Caucasian and Latin\u2010American populations, the COMT gene polymorphisms are associated with FM risk and pain sensitivity in Korean FM patients, suggesting ethnic variation in COMT gene polymorphisms.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ejp.837","type":"journal-article","created":{"date-parts":[[2016,2,5]],"date-time":"2016-02-05T14:51:06Z","timestamp":1454683866000},"page":"1131-1139","source":"Crossref","is-referenced-by-count":20,"title":["Association between catechol\u2010O\u2010methyl transferase gene polymorphisms and fibromyalgia in a Korean population: A case\u2013control study"],"prefix":"10.1002","volume":"20","author":[{"given":"D.J.","family":"Park","sequence":"first","affiliation":[{"name":"Department of Rheumatology Chonnam National University Medical School and Hospital Gwangju Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.H.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Inje University Haeundae Paik Hospital Busan Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.S.","family":"Nah","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Soonchunhyang University College of Medicine Cheonan Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.H.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Maryknoll Medical Center Busan Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.K.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Catholic University of Daegu School of Medicine Daegu 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