{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:04:32Z","timestamp":1790705072066,"version":"4.1.0"},"reference-count":65,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,3,15]],"date-time":"2016-03-15T00:00:00Z","timestamp":1458000000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Preoperative administration of pharmacological substances, such as non\u2010steroidal anti\u2010inflammatory drugs or opioids, has been gaining acclaim as a preemptive measure to minimize postoperative pain. This systematic review and meta\u2010analysis aimed at evaluating the effectiveness of this approach in adults undergoing surgical procedures. <jats:styled-content style=\"fixed-case\">MEDLINE<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> EMBASE<\/jats:styled-content> and the Cochrane Central Register were searched from inception through January 2015. Data from randomized placebo\u2010controlled trials were screened, extracted and assessed for risk of bias according to The Cochrane Collaboration's Tool by two independent authors. The primary outcome measure was reduction in postoperative analgesic consumption during 24\u00a0h post surgery; effects were described as mean differences between the drug and placebo arms with corresponding 95% confidence intervals (<jats:styled-content style=\"fixed-case\">CIs<\/jats:styled-content>) and were pooled using random\u2010effects models. Potential publication bias was tested using funnel plots and Egger's regression test for funnel plot asymmetry. Screened were 511 records, of which 39 were included in the final synthesis with data from 3172 patients. A significant reduction in postoperative analgesic consumption was observed using preoperative administration of non\u2010steroidal anti\u2010inflammatory drugs (<jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content>s; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, \u22120.61 to \u22120.14; 31 comparisons), chiefly by the <jats:styled-content style=\"fixed-case\">COX<\/jats:styled-content>\u20102 inhibitors class (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, \u22120.95 to \u22120.33; 13 comparisons). Significant reduction was also observed for gabapentin (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, \u22121.60 to \u22120.38; 6 comparisons). No significant effects were observed using opioids, propionic acids or oxicam derivatives.<\/jats:p><\/jats:sec><jats:sec><jats:title>What does this review add?<\/jats:title><jats:p>Current analyses endorse the effectiveness of COX\u20102 inhibitors and gabapentin in reducing acute postoperative pain when administered preemptively presurgery.<\/jats:p><jats:p>Such corroboration is not found for opioids and other NSAID classes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ejp.842","type":"journal-article","created":{"date-parts":[[2016,3,19]],"date-time":"2016-03-19T01:03:01Z","timestamp":1458349381000},"page":"1025-1043","source":"Crossref","is-referenced-by-count":56,"title":["Preoperative preemptive drug administration for acute postoperative pain: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"20","author":[{"given":"R.\u2010R.","family":"Nir","sequence":"first","affiliation":[{"name":"Department of Neurology Rambam Health Care Campus Haifa 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