{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T20:36:37Z","timestamp":1790195797623,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,2,23]],"date-time":"2016-02-23T00:00:00Z","timestamp":1456185600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Prof. Schmidtmann Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Chronic spontaneous pain is a clinically relevant non\u2010motor symptom in multiple system atrophy (<jats:styled-content style=\"fixed-case\">MSA<\/jats:styled-content>) and Parkinson's disease (<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>). Experimental pain sensitivity, reflecting the mechanisms of nociception and pain perception leading to clinical pain, is known to be enhanced in both diseases at advanced stages. Also, this study aimed at investigating experimental pain sensitivity already at an early stage (i.e. symptom duration \u22645\u00a0years).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Experimental pain sensitivity was assessed by investigating the nociceptive flexion reflex (<jats:styled-content style=\"fixed-case\">NFR<\/jats:styled-content>, reflecting spinal nociception) and heat and electrical pain thresholds. \u2018Off\u2010drug\u2019 <jats:styled-content style=\"fixed-case\">MSA<\/jats:styled-content> (<jats:italic>n<\/jats:italic>\u00a0=\u00a011) and <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> (<jats:italic>n<\/jats:italic>\u00a0=\u00a014) patients selected at an early stage of the disease were compared to healthy controls (<jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>,<jats:italic> n<\/jats:italic>\u00a0=\u00a027). <jats:styled-content style=\"fixed-case\">MSA<\/jats:styled-content> patients had either parkinsonian (<jats:styled-content style=\"fixed-case\">MSA<\/jats:styled-content>\u2010P, <jats:italic>n\u00a0<\/jats:italic>=\u00a05) or cerebellar (<jats:styled-content style=\"fixed-case\">MSA<\/jats:styled-content>\u2010C, <jats:italic>n<\/jats:italic>\u00a0=\u00a06) subtypes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> MSA<\/jats:styled-content> patients had lower heat pain sensitivity, whereas <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> patients had reduced <jats:styled-content style=\"fixed-case\">NFR<\/jats:styled-content> threshold. <jats:styled-content style=\"fixed-case\">MSA<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> patients did not differ from <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content> regarding other variables. <jats:styled-content style=\"fixed-case\">MSA<\/jats:styled-content>\u2010P and <jats:styled-content style=\"fixed-case\">MSA<\/jats:styled-content>\u2010C patients did not differ, either.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Impaired sensory discrimination and attention deficits could contribute to the reduced perception of heat pain in <jats:styled-content style=\"fixed-case\">MSA<\/jats:styled-content>, whereas in <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>, local changes in spinal excitability or a diminished dopaminergic descending inhibition might impact on the motor efference of the <jats:styled-content style=\"fixed-case\">NFR<\/jats:styled-content> to reduce its threshold to nociceptive afferent information.<\/jats:p><\/jats:sec><jats:sec><jats:title>What does this study add?<\/jats:title><jats:p>This study investigated experimental pain sensitivity at an early stage in MSA and PD.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ejp.846","type":"journal-article","created":{"date-parts":[[2016,2,26]],"date-time":"2016-02-26T02:21:03Z","timestamp":1456453263000},"page":"1223-1228","source":"Crossref","is-referenced-by-count":20,"title":["Experimental pain sensitivity in multiple system atrophy and Parkinson's disease at an early stage"],"prefix":"10.1002","volume":"20","author":[{"given":"V.","family":"Mylius","sequence":"first","affiliation":[{"name":"Department of Neurology Philipps University Marburg Germany"},{"name":"Center for Neurorehabilitation Valens Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Pee","sequence":"additional","affiliation":[{"name":"Department of Neurology Philipps University Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Pape","sequence":"additional","affiliation":[{"name":"Department of Neurology Philipps University Marburg 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