{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T17:04:11Z","timestamp":1782234251132,"version":"3.54.5"},"reference-count":36,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,4,18]],"date-time":"2016-04-18T00:00:00Z","timestamp":1460937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008364","name":"Tandl\u00e6geforeningen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008364","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008392","name":"Sundhed og Sygdom, Det Frie Forskningsr\u00e5d","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008392","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>A randomized, double\u2010blinded, placebo\u2010controlled study was conducted to investigate if single monosodium glutamate (MSG) administration would elevate muscle\/serum glutamate concentrations and affect muscle pain sensitivity in myofascial temporomandibular disorders (TMD) patients more than in healthy individuals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twelve myofascial TMD patients and 12 sex\u2010 and age\u2010matched healthy controls participated in two sessions. Participants drank MSG (150\u00a0mg\/kg) or NaCl (24\u00a0mg\/kg; control) diluted in 400\u00a0mL of soda. The concentration of glutamate in the masseter muscle, blood plasma and saliva was determined before and after the ingestion of MSG or control. At baseline and every 15\u00a0min after the ingestion, pain intensity was scored on a 0\u201310 numeric rating scale. Pressure pain threshold, pressure pain tolerance (PPTol) and autonomic parameters were measured. All participants were asked to report adverse effects after the ingestion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In TMD, interstitial glutamate concentration was significantly greater after the MSG ingestion when compared with healthy controls. TMD reported a mean pain intensity of 2.8\/10 at baseline, which significantly increased by 40% 30\u00a0min post MSG ingestion. At baseline, TMD showed lower PPTols in the masseter and trapezius, and higher diastolic blood pressure and heart rate than healthy controls. The MSG ingestion resulted in reports of headache by half of the TMD and healthy controls, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These findings suggest that myofascial TMD patients may be particularly sensitive to the effects of ingested MSG.<\/jats:p><\/jats:sec><jats:sec><jats:title>What does this study add?\u2019<\/jats:title><jats:p>\n<jats:list>\n\n<jats:list-item><jats:p>Elevation of interstitial glutamate concentration in the masseter muscle caused by monosodium glutamate (MSG) ingestion was significantly greater in myofascial myofascial temporomandibular disorders (TMD) patients than healthy individuals.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>This elevation of interstitial glutamate concentration in the masseter muscle significantly increased the intensity of spontaneous pain in myofascial TMD patients.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><\/jats:sec>","DOI":"10.1002\/ejp.874","type":"journal-article","created":{"date-parts":[[2016,4,19]],"date-time":"2016-04-19T02:52:40Z","timestamp":1461034360000},"page":"1502-1512","source":"Crossref","is-referenced-by-count":27,"title":["Increased pain and muscle glutamate concentration after single ingestion of monosodium glutamate by myofascial temporomandibular disorders patients"],"prefix":"10.1002","volume":"20","author":[{"given":"A.","family":"Shimada","sequence":"first","affiliation":[{"name":"Section\u00a0of Orofacial Pain and Jaw Function Department of Dentistry Faculty of Health Sciences Aarhus University Denmark"},{"name":"Scandinavian Center for Orofacial Neurosciences (SCON) Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.E.","family":"Castrillon","sequence":"additional","affiliation":[{"name":"Section\u00a0of Orofacial Pain and Jaw Function Department of Dentistry Faculty of Health Sciences Aarhus University Denmark"},{"name":"Scandinavian Center for Orofacial Neurosciences (SCON) Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Baad\u2010Hansen","sequence":"additional","affiliation":[{"name":"Section\u00a0of Orofacial Pain and Jaw Function Department of Dentistry Faculty of Health Sciences Aarhus University Denmark"},{"name":"Scandinavian Center for Orofacial Neurosciences (SCON) Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Ghafouri","sequence":"additional","affiliation":[{"name":"Division of Community Medicine Department of Medical and Health Sciences Faculty of Health Sciences Pain and Rehabilitation Center Anaesthetics, Operations and Specialty Surgery Center County Council of \u00d6sterg\u00f6tland Link\u00f6ping University Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Gerdle","sequence":"additional","affiliation":[{"name":"Division of Community Medicine Department of Medical and Health Sciences Faculty of Health Sciences Pain and Rehabilitation Center Anaesthetics, Operations and Specialty Surgery Center County Council of \u00d6sterg\u00f6tland Link\u00f6ping University Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"W\u00e5hl\u00e9n","sequence":"additional","affiliation":[{"name":"Division of Community Medicine Department of Medical and Health Sciences Faculty of Health Sciences Pain and Rehabilitation Center Anaesthetics, Operations and Specialty Surgery Center County Council of \u00d6sterg\u00f6tland Link\u00f6ping University Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Ernberg","sequence":"additional","affiliation":[{"name":"Scandinavian Center for Orofacial Neurosciences (SCON) Aarhus Denmark"},{"name":"Section\u00a0of Orofacial Pain and Jaw Function Department of Dental Medicine Karolinska Institute Huddinge Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.E.","family":"Cairns","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences The University of British Columbia Vancouver Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Svensson","sequence":"additional","affiliation":[{"name":"Section\u00a0of Orofacial Pain and Jaw Function Department of Dentistry Faculty of Health Sciences Aarhus University Denmark"},{"name":"Scandinavian Center for Orofacial Neurosciences (SCON) Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,4,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2009.01881.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-006-0109-x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4274(82)90070-4"},{"key":"e_1_2_7_5_1","volume-title":"Physiological Properties of Thin\u2010Fiber Muscle Afferents: Excitation and Modulatory Effects","author":"Cairns B.E.","year":"2008"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(01)00489-4"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2007.01.023"},{"key":"e_1_2_7_8_1","first-page":"216","article-title":"Effect of a peripheral NMDA receptor antagonist on glutamate\u2010evoked masseter muscle pain and mechanical sensitization in women","volume":"21","author":"Castrillon E.E.","year":"2007","journal-title":"J Orofac Pain"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2008.01.008"},{"key":"e_1_2_7_10_1","first-page":"350","article-title":"Interstitial glutamate concentration is elevated in the masseter muscle of myofascial temporomandibular disorder patients","volume":"24","author":"Castrillon E.E.","year":"2010","journal-title":"J Orofac Pain"},{"key":"e_1_2_7_11_1","first-page":"129","volume-title":"Orofacial Pain: Guidelines for Assessment, Diagnosis, and Management","author":"DeLeeuw R.","year":"2008"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2009.07.031"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002508-199306000-00002"},{"key":"e_1_2_7_14_1","first-page":"301","article-title":"Research diagnostic criteria for temporomandibular disorders: Review, criteria, examinations and specifications, critique","volume":"6","author":"Dworkin S.F.","year":"1992","journal-title":"J Craniomandib Disord"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(99)00250-7"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2842.2012.02308.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2010.03.005"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.962"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2010.07.029"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2000.110794"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2013.05.002"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.2000.278.1.E83"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910208100412"},{"key":"e_1_2_7_24_1","first-page":"13","volume-title":"Orofacial Pain: From Basic Science to Clinical Management","author":"LeResche L.","year":"2008"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2006.10.012"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2842.2009.02033.x"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2006.12.041"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.163.3869.826"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.2319\/0003-3219(2007)077[0471:ORFFTD]2.0.CO;2"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/1129-2377-14-2"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2014.07.011"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.3988\/jcn.2011.7.3.143"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(97)00156-5"},{"key":"e_1_2_7_34_1","first-page":"109","article-title":"Pain effects of glutamate injections into human jaw or neck muscles","volume":"19","author":"Svensson P.","year":"2005","journal-title":"J Orofac Pain"},{"key":"e_1_2_7_35_1","doi-asserted-by":"crossref","first-page":"1005S","DOI":"10.1093\/jn\/130.4.1005S","article-title":"Plasma amino acid patterns and visceral protein status in users and nonusers of monosodium glutamate","volume":"130","author":"Tanphaichitr V.","year":"2000","journal-title":"J Nutr"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(03)00074-5"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2000.0384"}],"container-title":["European Journal of Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fejp.874","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ejp.874","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T16:04:39Z","timestamp":1695571479000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ejp.874"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,18]]},"references-count":36,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["10.1002\/ejp.874"],"URL":"https:\/\/doi.org\/10.1002\/ejp.874","archive":["Portico"],"relation":{},"ISSN":["1090-3801","1532-2149"],"issn-type":[{"value":"1090-3801","type":"print"},{"value":"1532-2149","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,18]]}}}