{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T20:27:50Z","timestamp":1781296070382,"version":"3.54.1"},"reference-count":39,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2016,4,18]],"date-time":"2016-04-18T00:00:00Z","timestamp":1460937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Finnish Ministry of Education and Culture","award":["253715"],"award-info":[{"award-number":["253715"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and objective<\/jats:title><jats:p>The role of leisure\u2010time physical activity in sciatica is uncertain. This study aimed to assess the association of leisure\u2010time physical activity with lumbar radicular pain and sciatica.<\/jats:p><\/jats:sec><jats:sec><jats:title>Databases and data treatment<\/jats:title><jats:p>Literature searches were conducted in PubMed, Embase, Web of Science, Scopus, Google Scholar and ResearchGate databases from 1964 through August 2015. A random\u2010effects meta\u2010analysis was performed, and heterogeneity and small\u2010study bias were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ten cohort (<jats:italic>N<\/jats:italic>\u00a0=\u00a082,024 participants), four case\u2013control (<jats:italic>N<\/jats:italic>\u00a0=\u00a09350) and four cross\u2010sectional (<jats:italic>N<\/jats:italic>\u00a0=\u00a010,046) studies qualified for meta\u2010analysis. In comparison with no regular physical activity, high level of physical activity (\u22654 times\/week) was inversely associated with new onset of lumbar radicular pain or sciatica in a meta\u2010analysis of prospective cohort studies [risk ratio (RR)\u00a0=\u00a00.88, 95% CI 0.78\u20130.99, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a00%, 7 studies, <jats:italic>N<\/jats:italic>\u00a0=\u00a078,065]. The association for moderate level of physical activity (1\u20133 times\/week) was weaker (RR\u00a0=\u00a00.93, CI 0.82\u20131.05, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a00%, 6 studies, <jats:italic>N<\/jats:italic>\u00a0=\u00a069,049), and there was no association with physical activity for at least once\/week (RR\u00a0=\u00a00.99, CI 0.86\u20131.13, 9 studies, <jats:italic>N<\/jats:italic>\u00a0=\u00a073,008). In contrast, a meta\u2010analysis of cross\u2010sectional studies showed a higher prevalence of lumbar radicular pain or sciatica in participants who exercised at least once\/week [prevalence ratio (PR)\u00a0=\u00a01.29, CI 1.09\u20131.53, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a00%, 4 studies, <jats:italic>N<\/jats:italic>\u00a0=\u00a010,046], or 1\u20133 times\/week (PR\u00a0=\u00a01.34, CI 1.02\u20131.77, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a00%, <jats:italic>N<\/jats:italic>\u00a0=\u00a07631) than among inactive participants. There was no evidence of small\u2010study bias.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This meta\u2010analysis suggests that moderate to high level of leisure physical activity may have a moderate protective effect against development of lumbar radicular pain. However, a large reduction in risk (&gt;30%) seems unlikely.<\/jats:p><\/jats:sec><jats:sec><jats:title>What does this review add<\/jats:title><jats:p>Leisure\u2010time physical activity may reduce the risk of developing lumbar radicular pain.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ejp.885","type":"journal-article","created":{"date-parts":[[2016,4,19]],"date-time":"2016-04-19T03:12:37Z","timestamp":1461035557000},"page":"1563-1572","source":"Crossref","is-referenced-by-count":26,"title":["Leisure\u2010time physical activity and sciatica: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"20","author":[{"given":"R.","family":"Shiri","sequence":"first","affiliation":[{"name":"Finnish Institute of Occupational Health Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Falah\u2010Hassani","sequence":"additional","affiliation":[{"name":"Lawrence S. 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