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Our hypothesis is that 25% glucose is more effective in relieving pain than non\u2010nutritive sucking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A randomized clinical trial with 78 healthy newborns was performed. Neonates were assigned randomly to receive 25% glucose (G25) and non\u2010nutritive sucking (<jats:styled-content style=\"fixed-case\">NNS<\/jats:styled-content>). Pain was assessed using the Neonatal Infant Pain Scale (<jats:styled-content style=\"fixed-case\">NIPS<\/jats:styled-content>) before and during the immunization procedure. In addition, we evaluated various physiological parameters and crying time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Neonates who received 25% glucose registered lower <jats:styled-content style=\"fixed-case\">NIPS<\/jats:styled-content> scores than those from the <jats:styled-content style=\"fixed-case\">NNS<\/jats:styled-content> group [mean (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>), 3.3 (2.1) vs. 5.6 (1.6), <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001]. The crying time was shorter among newborns in the G25 group than in the <jats:styled-content style=\"fixed-case\">NNS<\/jats:styled-content> and control groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The use of 25% glucose before the vaccination procedure was more effective in relieving acute pain, with newborns in the G25 group registering scores two times lower on the <jats:styled-content style=\"fixed-case\">NIPS<\/jats:styled-content> scale. The clinical practice of administering 25% glucose is therefore a suggested nondrug measure for pain relief during painful procedures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>Neonates who received 25% glucose registered lower <jats:styled-content style=\"fixed-case\">NIPS<\/jats:styled-content> scores than those from the <jats:styled-content style=\"fixed-case\">NNS<\/jats:styled-content> group; the crying time was shorter among newborns in the G25 group than in the <jats:styled-content style=\"fixed-case\">NNS<\/jats:styled-content> and control groups; the use of 25% glucose before the vaccination procedure was more effective in relieving acute pain.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ejp.912","type":"journal-article","created":{"date-parts":[[2016,7,27]],"date-time":"2016-07-27T03:42:43Z","timestamp":1469590963000},"page":"159-165","source":"Crossref","is-referenced-by-count":22,"title":["Glucose solution is more effective in relieving pain in neonates than non\u2010nutritive sucking: A randomized clinical trial"],"prefix":"10.1002","volume":"21","author":[{"given":"A.G.C.F.","family":"Lima","sequence":"first","affiliation":[{"name":"Postgraduate Program in Health Sciences Federal University of Sergipe Aracaju Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.S.","family":"Santos","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Health Sciences Federal University of Sergipe Aracaju Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.S.","family":"Nunes","sequence":"additional","affiliation":[{"name":"Department of Nursing Federal University of Sergipe Lagarto Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.A.A","family":"Barreto","sequence":"additional","affiliation":[{"name":"Department of Nursing Federal University of Sergipe Lagarto Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.J.N.","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Health Sciences Federal University of Sergipe Aracaju Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Department of Nursing Federal University of Sergipe Aracaju Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.C.O.","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Health Sciences Federal University of Sergipe Aracaju Brazil"},{"name":"Department of Nursing Federal University of Sergipe Aracaju Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,7,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/AJP.0b013e318181ad81"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmn.2010.07.002"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/chemse\/20.1.29"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-0993"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.4324\/9781315806730"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-536X.2010.00389.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncpneuro0984"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2012.02.024"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1155\/2001\/376819"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.enfcli.2009.05.004"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2014.08.010"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2007.01.033"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijnurstu.2011.09.013"},{"key":"e_1_2_6_15_1","first-page":"59","article-title":"The development of a tool to assess neonatal pain","volume":"12","author":"Lawrence J.","year":"1993","journal-title":"Neonatal Netw"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2011.02.016"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2702.2009.03014.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2015.03.019"},{"key":"e_1_2_6_19_1","first-page":"233","article-title":"The reality of neonatal pain","volume":"2","author":"Puchalski M.","year":"2002","journal-title":"Adv Neonatal Care"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpc.12392"},{"key":"e_1_2_6_21_1","unstructured":"Romano J. 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