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Other hormones were studied in patients with different other chronic pain conditions. Considering the accumulation of sufficient knowledge about the role of disadaptation processes in <jats:styled-content style=\"fixed-case\">CRPS<\/jats:styled-content> I pathogenesis and the role of the hypothalamic\u2010pituitary\u2010adrenal and hypothalamic\u2010pituitary\u2010ovarian systems in the process of adaptation it was logical and consistent to define the role of hormonal dysregulation of these systems in patients with <jats:styled-content style=\"fixed-case\">CRPS<\/jats:styled-content> I.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Our objective was to determine the role of hypothalamic\u2010pituitary\u2010adrenal and hypothalamic\u2010pituitary\u2010ovarian systems in pathogenesis of complex regional pain syndrome type I (<jats:styled-content style=\"fixed-case\">CRPS<\/jats:styled-content> I) in women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We investigated the pituitary gonadotropic function and the function of sex glands in women with <jats:styled-content style=\"fixed-case\">CRPS<\/jats:styled-content> I and healthy volunteers by measuring the plasma levels of estradiol (E<jats:sub>2<\/jats:sub>), follicle\u2010stimulating hormone, luteinizing hormone, prolactin, adrenocorticotropic hormone, and cortisol, and urinary excretion of 17\u2010ketosteroids, 17\u2010oxycocorticosteroids, epinephrine and norepinephrine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Women with <jats:styled-content style=\"fixed-case\">CRPS<\/jats:styled-content> I were characterized by the decreased content of oestrogens in the blood plasma and increased pituitary gonadotrophic function. The disturbed ratio of anabolic and catabolic steroids in women with <jats:styled-content style=\"fixed-case\">CRPS<\/jats:styled-content> I was detected due to lower adrenal cortex function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In patients with <jats:styled-content style=\"fixed-case\">CRPS<\/jats:styled-content> I endocrine status is characterized by hormonal imbalances of the hypothalamic\u2010pituitary\u2010adrenal and hypothalamic\u2010pituitary\u2010gonadal systems. The changes in reproductive and adaptation homeostasis characterize <jats:styled-content style=\"fixed-case\">CRPS<\/jats:styled-content> I as a form of the disease of disadaptation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>This study determined the role of hypothalamic\u2010pituitary\u2010adrenal and hypothalamic\u2010pituitary\u2010ovarian systems in pathogenesis of <jats:styled-content style=\"fixed-case\">CRPS<\/jats:styled-content> I.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ejp.924","type":"journal-article","created":{"date-parts":[[2016,8,10]],"date-time":"2016-08-10T05:38:33Z","timestamp":1470807513000},"page":"302-308","source":"Crossref","is-referenced-by-count":15,"title":["Endocrine disorders in women with complex regional pain syndrome type I"],"prefix":"10.1002","volume":"21","author":[{"given":"A.","family":"Buryanov","sequence":"first","affiliation":[{"name":"Department of Orthopedics and Traumatology National Medical University n.a. 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