{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T01:59:12Z","timestamp":1783475952282,"version":"3.55.0"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,11,8]],"date-time":"2016-11-08T00:00:00Z","timestamp":1478563200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Systemic gabapentin is a mainstay treatment for neuropathic pain though there are side\u2010effects. Localized therapy may curtail such side\u2010effects so a topical gabapentin dermal application was examined in the chronic constriction injury (<jats:styled-content style=\"fixed-case\">CCI<\/jats:styled-content>) model of neuropathic pain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Partial denervation <jats:styled-content style=\"fixed-case\">CCI<\/jats:styled-content> was achieved by rat sciatic nerve ligation. Gabapentin gel (10% w\/w) was applied three times daily on the ipsilateral or contralateral plantar surface of the hind\u2010paw, whereas in a concurrent systemic study, gabapentin was intraperitoneally administered daily (75\u00a0mg\/kg) for 30\u00a0days. Tests for static\u2010 and dynamic\u2010mechano\u2010allodynia [paw withdrawal threshold (<jats:styled-content style=\"fixed-case\">PWT<\/jats:styled-content>) to von Frey filament application and latency (<jats:styled-content style=\"fixed-case\">PWL<\/jats:styled-content>) to light brushing], cold\u2010allodynia [paw withdrawal duration (<jats:styled-content style=\"fixed-case\">PWD<\/jats:styled-content>) to acetone], heat\u2010 (<jats:styled-content style=\"fixed-case\">PWL<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">PWD<\/jats:styled-content>) and mechano\u2010hyperalgesia (<jats:styled-content style=\"fixed-case\">PWD<\/jats:styled-content> to pin prick) were utilized to assess pain, whereas effects on locomotion (open field) and motor balance (rotarod and footprint analysis) were measured on days 5\u201330 post surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Topical application of gabapentin gel ipsilaterally but not contralaterally alleviated <jats:styled-content style=\"fixed-case\">CCI<\/jats:styled-content>\u2010induced static\u2010 (days 10\u201330) and dynamic\u2010allodynia (days 15\u201330), suppressed cold\u2010allodynia (days 10\u201330), heat\u2010 (days 15\u201330) and mechano\u2010hyperalgesia (days 5\u201330) indicating a local action. Systemic gabapentin exhibited similar pain profiles but was associated with motor impairment. The gabapentin gel formulation afforded desirable neuropathic pain alleviating effects devoid of unwanted systemic side\u2010effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These outcomes disclose an expedient pharmacological validation of the effectiveness of topical gabapentin gel against an extensive range of nociceptive stimulus modalities utilizing the <jats:styled-content style=\"fixed-case\">CCI<\/jats:styled-content>\u2010induced neuropathic pain model. They also advocate further clinical studies on topical gabapentin with regard to certain neuropathic pain syndromes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>Systemic gabapentin neuropathic pain management carries side\u2010effects ostensibly preventable by localized therapy. This study validates the effectiveness potential of a topical gabapentin gel against an extensive range of nociceptive stimulus modalities utilizing the chronic constriction injury\u2010induced neuropathic pain model.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ejp.971","type":"journal-article","created":{"date-parts":[[2016,11,8]],"date-time":"2016-11-08T12:42:44Z","timestamp":1478608964000},"page":"668-680","source":"Crossref","is-referenced-by-count":47,"title":["Topical gabapentin gel alleviates allodynia and hyperalgesia in the chronic sciatic nerve constriction injury neuropathic pain model"],"prefix":"10.1002","volume":"21","author":[{"given":"M.","family":"Shahid","sequence":"first","affiliation":[{"name":"Department of Pharmacy Sarhad University of Science and Information Technology Peshawar Pakistan"},{"name":"Department of Pharmacy University of Peshawar 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