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The unsatisfactory management of <jats:styled-content style=\"fixed-case\">PHN<\/jats:styled-content> partly results from the difficulty in dissecting out its contributing factors due to the complexity of <jats:styled-content style=\"fixed-case\">PHN<\/jats:styled-content> mechanism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Here, to elaborate our understanding of the <jats:styled-content style=\"fixed-case\">PHN<\/jats:styled-content> mechanism and to establish a basis for effective therapeutic strategies, we comprehensively investigated the contributions of multiple factors to <jats:styled-content style=\"fixed-case\">PHN<\/jats:styled-content> severity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Based on the comparison of somatosensory detection thresholds (C, A\u03b4 and A\u03b2 fibre thresholds) between affected and unaffected sides, 16 <jats:styled-content style=\"fixed-case\">PHN<\/jats:styled-content> patients with significant sensory deficits and 13 <jats:styled-content style=\"fixed-case\">PHN<\/jats:styled-content> patients without significant sensory deficits were identified and assigned to different groups. The different extents of lesions in the nociceptive system between patients with and without sensory deficits were confirmed using laser\u2010evoked brain responses. Moreover, patients with sensory deficits had more severe pain and psychological disorders, e.g. anxiety and depression. Importantly, chronic pain severity was significantly influenced by various psychophysiological factors (sleep disturbances, psychological disorders and hypothalamic\u2010pituitary\u2010adrenal axis dysfunction) for patients with sensory deficits.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings demonstrated the contribution of multiple patho\u2010psychophysiological factors to <jats:styled-content style=\"fixed-case\">PHN<\/jats:styled-content> severity, which could help establish a basis for the development of a rational, patient\u2010centred therapeutic strategy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>This study revealed the contribution of multiple patho\u2010psychophysiological factors to <jats:styled-content style=\"fixed-case\">PHN<\/jats:styled-content> severity, which expanded our understanding of the underlying <jats:styled-content style=\"fixed-case\">PHN<\/jats:styled-content> mechanism, and helped develop a rational, patient\u2010centred therapeutic strategy targeting towards the corresponding etiology and psychophysiological disorders for individual patient.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ejp.985","type":"journal-article","created":{"date-parts":[[2016,12,17]],"date-time":"2016-12-17T10:16:42Z","timestamp":1481969802000},"page":"827-842","source":"Crossref","is-referenced-by-count":21,"title":["Biological mechanism of post\u2010herpetic neuralgia: Evidence from multiple patho\u2010psychophysiological measures"],"prefix":"10.1002","volume":"21","author":[{"given":"W.W.","family":"Peng","sequence":"first","affiliation":[{"name":"Brain Function and Psychological Science Research Center Shenzhen University Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.L.","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Pain Medicine, Daping Hospital &amp; Research Institute of Surgery The Third Military Medical University 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