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The time course of <jats:styled-content style=\"fixed-case\">LEP<\/jats:styled-content>\u2010habituation is reduced in the capsaicin model for peripheral and central sensitization and in patients with migraine and fibromyalgia. In the present investigation, we aimed to assess the time course of <jats:styled-content style=\"fixed-case\">LEP<\/jats:styled-content>\u2010habituation in a neuropathic pain syndrome, i.e. painful radiculopathy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>At the side of radiating pain, four blocks of 25 painful laser stimuli each were applied to the ventral thigh at the L3 dermatome in 27 patients with painful radiculopathy. Inclusion criteria were (1) at least one neurological finding of radiculopathy, (2) low back pain with radiation into the foot and (3) a positive one\u2010sided compression of the L5 and\/or S1 root in the <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>. The time course of <jats:styled-content style=\"fixed-case\">LEP<\/jats:styled-content>\u2010habituation was compared to 20 healthy height and age matched controls. Signs of peripheral (heat hyperalgesia) and central sensitization (dynamic mechanical allodynia and hyperalgesia) at the affected L5 or S1 dermatome were assessed with quantitative sensory testing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Painful radiculopathy patients showed decreased <jats:styled-content style=\"fixed-case\">LEP<\/jats:styled-content>\u2010habituation compared to controls. Patients with signs of central sensitization showed a more prominent <jats:styled-content style=\"fixed-case\">LEP<\/jats:styled-content>\u2010habituation decrease within the radiculopathy patient group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Laser\u2010evoked potential habituation is reduced in painful radiculopathy patients, which indicates an abnormal central pain processing. Central sensitization seems to be a major contributor to abnormal <jats:styled-content style=\"fixed-case\">LEP<\/jats:styled-content> habituation. The <jats:styled-content style=\"fixed-case\">LEP<\/jats:styled-content> habituation paradigm might be useful as a clinical tool to assess central pain processing alterations in nociceptive and neuropathic pain conditions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>Abnormal central pain processing in neuropathic pain conditions may be revealed with the laser\u2010evoked potential habituation paradigm. In painful radiculopathy patients, <jats:styled-content style=\"fixed-case\">LEP<\/jats:styled-content>\u2010habituation is reduced compared to healthy controls.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ejp.994","type":"journal-article","created":{"date-parts":[[2017,1,20]],"date-time":"2017-01-20T18:24:52Z","timestamp":1484936692000},"page":"918-926","source":"Crossref","is-referenced-by-count":34,"title":["Reduced laser\u2010evoked potential habituation detects abnormal central pain processing in painful radiculopathy patients"],"prefix":"10.1002","volume":"21","author":[{"given":"P.","family":"H\u00fcllemann","sequence":"first","affiliation":[{"name":"Division of Neurological Pain Research and Therapy Department of Neurology University Hospital Schleswig\u2010Holstein Campus Kiel Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"von der Brelie","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery University Hospital 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