{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T13:58:00Z","timestamp":1785333480874,"version":"3.55.0"},"reference-count":48,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,4,26]],"date-time":"2024-04-26T00:00:00Z","timestamp":1714089600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Sport Science"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The neurological effects and underlying pathophysiological mechanisms of sports\u2010related concussion (SRC) in active young boxers remain poorly understood. This study aims to investigate the impairment of white matter microstructure and assess changes in glymphatic function following SRC by utilizing neurite orientation dispersion and density imaging (NODDI) on young boxers who have sustained SRC. A total of 60 young participants were recruited, including 30 boxers diagnosed with SRC and 30 healthy individuals engaging in regular exercise. The assessment of whole\u2010brain white matter damage was conducted using diffusion metrics, while the evaluation of glymphatic function was performed through diffusion tensor imaging (DTI) analysis along the perivascular space (DTI\u2010ALPS) index. A two\u2010sample <jats:italic>t<\/jats:italic>\u2010test was utilized to examine group differences in DTI and NODDI metrics. Spearman correlation and generalized linear mixed models were employed to investigate the relationship between clinical assessments of SRC and NODDI measurements. Significant alterations were observed in DTI and NODDI metrics among young boxers with SRC. Additionally, the DTI\u2010ALPS index in the SRC group exhibited a significantly higher value than that of the control group (left side: 1.58 vs. 1.48, <jats:italic>P<\/jats:italic><jats:sub>FDR<\/jats:sub>\u00a0=\u00a00.009; right side: 1.61 vs. 1.51, <jats:italic>P<\/jats:italic><jats:sub>FDR<\/jats:sub>\u00a0=\u00a00.02). Moreover, it was observed that the DTI\u2010ALPS index correlated with poorer cognitive test results among boxers in this study population. Repetitive SRC in active young boxers is associated with diffuse white matter injury and glymphatic dysfunction, highlighting the detrimental impact on brain health. These findings highlight the importance of long\u2010term monitoring of the neurological health of boxers.<\/jats:p>","DOI":"10.1002\/ejsc.12113","type":"journal-article","created":{"date-parts":[[2024,4,27]],"date-time":"2024-04-27T05:12:56Z","timestamp":1714194776000},"page":"975-986","source":"Crossref","is-referenced-by-count":4,"title":["Neurite orientation dispersion and density imaging reveals abnormal white matter and glymphatic function in active young boxers"],"prefix":"10.1002","volume":"24","author":[{"given":"Wenjing","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Magnetic Resonance Lanzhou University Second Hospital  Lanzhou China"},{"name":"Second Clinical School Lanzhou University  Lanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laiyang","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Magnetic Resonance Lanzhou University Second Hospital  Lanzhou China"},{"name":"Second Clinical School Lanzhou University  Lanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahao","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Magnetic Resonance Lanzhou University Second Hospital  Lanzhou China"},{"name":"Second Clinical School Lanzhou University  Lanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanjun","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Magnetic Resonance Lanzhou University Second Hospital  Lanzhou China"},{"name":"Second Clinical School Lanzhou University  Lanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangyao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Magnetic Resonance Lanzhou University Second Hospital  Lanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Magnetic Resonance Lanzhou University Second Hospital  Lanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1678-5688","authenticated-orcid":false,"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Magnetic Resonance Lanzhou University Second Hospital  Lanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,26]]},"reference":[{"issue":"4","key":"e_1_2_9_2_1","article-title":"Anatomic Asymmetries of the Posterior Superior Temporal Lobes: a Postmortem Study","volume":"12","author":"Anderson B.","year":"1999","journal-title":"Neuropsychiatry Neuropsychology & Behavioral Neurology"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021\u20109290(98)00068\u20102"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.11.021"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2015\u20104635"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010020\u201063022\u20107"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.24500"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/HTR.0000000000000156"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2023.1148878"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3171\/2015.5.Peds15220"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/0706743716643741"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp\u20102019\u2010321170"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3171\/2023.6.Jns23260"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/03635465211027946"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11682\u2010020\u201000336\u20100"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.3171\/2010.6.Jns10207"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.26516"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1523\/Jneurosci.3020\u201014.2014"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3003748"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2002.1132"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330\u2010015\u20104066\u20108"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2020.108908"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awq347"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001199\u2010200609000\u201000001"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2020.147062"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhab161"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11682\u2010016\u20109546\u20101"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports\u20102017\u2010097699"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.40070"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjsm.36.5.346"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aaz6892"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00234\u2010022\u201003073\u2010x"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00234\u2010022\u201003073\u2010x"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478\u2010020\u20100895\u2010z"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.3171\/2023.2.Peds237"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2013.30"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awx191"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41531\u2010022\u201000437\u20101"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A3676"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2017.04.021"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.10062"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11604\u2010017\u20100617\u2010z"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1519\/jsc.0000000000003909"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaa140"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2019.6886"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.16142535"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.01.084"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2021.118257"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcab133"}],"container-title":["European Journal of Sport Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ejsc.12113","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T04:25:36Z","timestamp":1719980736000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ejsc.12113"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,26]]},"references-count":48,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["10.1002\/ejsc.12113"],"URL":"https:\/\/doi.org\/10.1002\/ejsc.12113","archive":["Portico"],"relation":{},"ISSN":["1746-1391","1536-7290"],"issn-type":[{"value":"1746-1391","type":"print"},{"value":"1536-7290","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,26]]}}}