{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T08:33:46Z","timestamp":1761294826303,"version":"3.44.0"},"reference-count":46,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T00:00:00Z","timestamp":1740355200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Sport Science"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Repeated sessions of eccentric\u2010biased exercise promote strength gains through neuromuscular adaptation. However, it remains unclear whether increasing the number of these sessions can mitigate the extent of neuromuscular fatigue and exercise\u2010induced muscle damage (EIMD) in response to a standardised eccentric\u2010biased bout. Twelve healthy untrained adults (five females and seven males; 25.1\u00a0\u00b1\u00a04.9\u00a0years; and : 49.4\u00a0\u00b1\u00a06.2\u00a0mL\u00a0kg<jats:sup>\u22121<\/jats:sup>\u00a0min<jats:sup>\u22121<\/jats:sup>) completed two blocks of five downhill running (DR) sessions on a motorised treadmill at a speed equivalent to 60%\u201365%  for 15\u201330\u00a0min. Knee extensor maximal voluntary isometric torque (MVT), electrically evoked measures of neuromuscular fatigue (peripheral and central components), and lower\u2010limb perceived muscle soreness (PMS) and perceived load (RPE\u00a0\u00d7\u00a0session duration) were assessed before and immediately after a 15 min standardised DR bout at baseline and after 5 and 10 DR sessions. MVT decreased following a standardised DR bout (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01) similarly at all three time points (\u221214%, \u221211% and \u22129%; <jats:italic>p<\/jats:italic>\u00a0&gt;\u00a00.05). The same observations were found for all peripheral and central neuromuscular fatigue indicators after 0, 5 and 10 DR sessions. <jats:italic>Quadriceps<\/jats:italic> (but not <jats:italic>plantar flexor<\/jats:italic> or <jats:italic>gluteus<\/jats:italic>) PMS was lower after 10 DR sessions (8.7\u00a0\u00b1\u00a08.5\u00a0mm) compared to baseline (29.6\u00a0\u00b1\u00a022.2\u00a0mm and <jats:italic>p<\/jats:italic>\u00a0=\u00a00.01), but no difference was observed after 5 DR sessions (15.4\u00a0\u00b1\u00a011.9\u00a0mm and <jats:italic>p<\/jats:italic>\u00a0=\u00a00.08). Ten repeated sessions of eccentric\u2010biased exercise led to a reduction in <jats:italic>quadriceps femoris<\/jats:italic> PMS following a standardised DR bout but neither 5 nor 10 sessions altered the central or peripheral fatigue responses to the same standardised DR bout. These findings suggest distinct physiological adaptations to repeated eccentric\u2010biased exercise regarding EIMD and neuromuscular fatigue.<\/jats:p>","DOI":"10.1002\/ejsc.12240","type":"journal-article","created":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T13:36:17Z","timestamp":1740490577000},"source":"Crossref","is-referenced-by-count":2,"title":["Muscle soreness but not neuromuscular fatigue responses following downhill running differ according to the number of exercise bouts"],"prefix":"10.1002","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4323-7804","authenticated-orcid":false,"given":"Bastien","family":"Bontemps","sequence":"first","affiliation":[{"name":"LAMHESS Universit\u00e9 C\u00f4te d'Azur  Nice France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9109-0958","authenticated-orcid":false,"given":"Julien","family":"Louis","sequence":"additional","affiliation":[{"name":"School of Sport and Exercise Sciences Liverpool John Moores University  Liverpool UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1908-8677","authenticated-orcid":false,"given":"Daniel J.","family":"Owens","sequence":"additional","affiliation":[{"name":"School of Sport and Exercise Sciences Liverpool John Moores University  Liverpool UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stella","family":"Mir\u00edc","sequence":"additional","affiliation":[{"name":"School of Sport and Exercise Sciences Liverpool John Moores University  Liverpool UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7109-177X","authenticated-orcid":false,"given":"Fabrice","family":"Vercruyssen","sequence":"additional","affiliation":[{"name":"Laboratory Youth\u2010Physical Activity and Sports\u2010Health (J\u2010AP2S) Universit\u00e9 de Toulon  Toulon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2658-277X","authenticated-orcid":false,"given":"Mathieu","family":"Gruet","sequence":"additional","affiliation":[{"name":"Laboratory Youth\u2010Physical Activity and Sports\u2010Health (J\u2010AP2S) Universit\u00e9 de Toulon  Toulon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5705-0207","authenticated-orcid":false,"given":"Robert M.","family":"Erskine","sequence":"additional","affiliation":[{"name":"School of Sport and Exercise Sciences Liverpool John Moores University  Liverpool UK"},{"name":"Institute of Sport, Exercise and Health University College London  London 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