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The main objective of this randomized cross\u2010over study was to investigate the effect of a moderately\u2010intense exercise bout on children's physiological and psychological reactions to a subsequent acute psychosocial stressor. On two separate laboratory appointments, 114 children (62 female) aged between 10 and 13\u00a0years completed the Trier Social Stress Test for Children (TSST\u2010C) and a nonstressful control task, respectively. Fifty\u2010seven participants engaged in an exercise bout prior to the conditions and were matched (based on sex, age, and everyday moderate\u2010to\u2010vigorous intensity physical activity) to a control group, who did not engage in a physically demanding task. Stress reactivity was assessed using saliva cortisol and heart rate (calculated area under the response curve) and self\u2010reported anxiety (post minus pre score). Repeated measures analyses of variance revealed main effects of condition, indicating higher stress reactivity in the TSST\u2010C compared to control for cortisol, heart rate, and anxiety. There were no significant interactions of group and condition. However, a three\u2010way interaction involving chronic stress indicated favorable cortisol reactivity patterns after acute exercise compared to the resting condition, but only for participants with higher levels of chronic stress. While results indicate no generalizable effect of acute exercise on children's physiological and psychological reactivity to acute psychosocial stress, acute exercise seems to transiently counteract chronic stress\u2010induced hyperreactivity of the hypothalamic\u2010pituitary\u2010adrenal axis.<\/jats:p>","DOI":"10.1002\/ejsc.12273","type":"journal-article","created":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T06:44:36Z","timestamp":1741070676000},"source":"Crossref","is-referenced-by-count":6,"title":["Does a Single Exercise Session Reduce the Reactivity to Acute Psychosocial Stress in Children?"],"prefix":"10.1002","volume":"25","author":[{"given":"Manuel","family":"Hanke","sequence":"first","affiliation":[{"name":"Department of Sport Exercise and Health Sport Science Section University of Basel  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Schwarz","sequence":"additional","affiliation":[{"name":"Department of Sport Exercise and Health Sport Science Section University of Basel  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera Nina","family":"Looser","sequence":"additional","affiliation":[{"name":"Department of Sport Exercise and Health Sport Science Section University of Basel  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Gerber","sequence":"additional","affiliation":[{"name":"Department of Sport Exercise and Health Sport Science Section University of Basel  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3905-7894","authenticated-orcid":false,"given":"Sebastian","family":"Ludyga","sequence":"additional","affiliation":[{"name":"Department of Sport Exercise and Health Sport Science Section University of Basel  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-021-01224-9"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2013.11.005"},{"issue":"1","key":"e_1_2_10_4_1","first-page":"1","article-title":"Physical Inactivity: The Biggest Public Health Problem of the 21st Century","volume":"43","author":"Blair S. 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