{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T06:19:07Z","timestamp":1772864347942,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T00:00:00Z","timestamp":1752019200000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["No 801790"],"award-info":[{"award-number":["No 801790"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Sport Science"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Physical activity (PA) has anti\u2010inflammatory effects, but its impact on individuals with multimorbidity (two or more chronic conditions) is unclear. We examined the association between device\u2010measured (i.e., accelerometers) PA and inflammatory biomarkers in people with multimorbidity. In a, preplanned, cross\u2010sectional analysis from the MOBILIZE trial, 214 participants with multimorbidity provided data on PA and inflammatory biomarkers including interleukin\u20101 receptor antagonist (IL\u20101ra), high\u2010sensitivity C\u2010reactive protein (hs\u2010CRP), tumor necrosis factor (TNF), and interleukin\u20106 (IL\u20106). The primary outcome was minutes per day of moderate\u2010to\u2010vigorous physical activity (MVPA). Adjusted robust regression models were used to evaluate associations, and BMI was explored as a mediator. Higher MVPA was associated with lower IL\u20101ra levels, with a 2% reduction in IL\u20101ra for each additional minute of MVPA per day. Participants with at least 10\u00a0min\/day of MVPA had 33%\u201345% lower IL\u20101ra levels compared to those with less than 1\u00a0min\/day. Similar results were observed for secondary outcomes. BMI did not mediate the MVPA\u2013IL\u20101ra relationship. Even small increases in MVPA appear to be associated with low\u2010grade inflammation in individuals with multimorbidity. These findings support the promotion of PA in line with WHO guidelines for physical activity even in people with multimorbidity.<\/jats:p>","DOI":"10.1002\/ejsc.70005","type":"journal-article","created":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T16:40:08Z","timestamp":1752079208000},"source":"Crossref","is-referenced-by-count":1,"title":["Device\u2010Based Physical Activity and Low\u2010Grade Inflammation in People With Multimorbidity: Cross\u2010Sectional Baseline Analysis From the MOBILIZE\u00a0Trial"],"prefix":"10.1002","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9717-918X","authenticated-orcid":false,"given":"Alessio","family":"Bricca","sequence":"first","affiliation":[{"name":"Center for Muscle and Joint Health Department of Sports Science and Clinical Biomechanics University of Southern Denmark  Odense Denmark"},{"name":"The Research and Implementation Unit PROgrez Department of Physiotherapy and Occupational Therapy N\u00e6stved\u2010Slagelse\u2010Ringsted Hospitals  Slagelse Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grit Elster","family":"Legaard","sequence":"additional","affiliation":[{"name":"Centre for Physical Activity Research Rigshospitalet  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sofie Rath","family":"Mortensen","sequence":"additional","affiliation":[{"name":"The Research and Implementation Unit PROgrez Department of Physiotherapy and Occupational Therapy N\u00e6stved\u2010Slagelse\u2010Ringsted Hospitals  Slagelse Denmark"},{"name":"Research Unit for Exercise Epidemiology Centre of Research in Childhood Health Department of Sports Science and Clinical Biomechanics University of Southern Denmark  Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan Christian","family":"Br\u00f8nd","sequence":"additional","affiliation":[{"name":"Research Unit for Exercise Epidemiology Centre of Research in Childhood Health Department of Sports Science and Clinical Biomechanics University of Southern Denmark  Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"G\u00e6de","sequence":"additional","affiliation":[{"name":"Department of Regional Health Research University of Southern Denmark  Odense Denmark"},{"name":"Department of Cardiology and Endocrinology Slagelse Hospital  Slagelse Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00f8ren T.","family":"Skou","sequence":"additional","affiliation":[{"name":"Center for Muscle and Joint Health Department of Sports Science and Clinical Biomechanics University of Southern Denmark  Odense Denmark"},{"name":"The Research and Implementation Unit PROgrez Department of Physiotherapy and Occupational Therapy N\u00e6stved\u2010Slagelse\u2010Ringsted Hospitals  Slagelse Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,9]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annepidem.2022.09.009"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40814\u2010022\u201001204\u2010y"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/cpf.12571"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1249\/mss.0000000000001344"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports\u20102020\u2010102955"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1017\/s0007114512005119"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0139984"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmedr.2023.102483"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmedr.2023.102265"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010019\u20100675\u20100"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3041"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/brs.0000000000004385"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1123\/jpah.10.5.742"},{"key":"e_1_2_11_15_1","volume-title":"Robust Regression. 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