{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T17:45:19Z","timestamp":1755798319461,"version":"3.44.0"},"reference-count":38,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,7,18]],"date-time":"2025-07-18T00:00:00Z","timestamp":1752796800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012456","name":"National Social Science Fund of China","doi-asserted-by":"publisher","award":["21BTY092"],"award-info":[{"award-number":["21BTY092"]}],"id":[{"id":"10.13039\/501100012456","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Sport Science"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>This study aimed to compare physiological responses to high\u2010intensity interval exercise (HIIE) in hypoxia and normoxia across different body mass index (BMI) categories. Twenty\u2010one males, classified as normal\u2010weight (NW, <jats:italic>n<\/jats:italic>\u00a0=\u00a09 and BMI: 22.9\u00a0\u00b1\u00a02.3\u00a0kg\u00a0\u00b7\u00a0m<jats:sup>\u22122<\/jats:sup>) or overweight\/obese (OW, <jats:italic>n<\/jats:italic>\u00a0=\u00a012 and BMI: 27.6\u00a0\u00b1\u00a02.0\u00a0kg\u00a0\u00b7\u00a0m<jats:sup>\u22122<\/jats:sup>), completed graded exercise tests (GXT) in normoxia (FiO<jats:sub>2<\/jats:sub>\u00a0=\u00a020.9%) and hypoxia (FiO<jats:sub>2<\/jats:sub>\u00a0=\u00a014.0%), followed by three randomised HIIE sessions: hypoxia (HY), normoxia matched to hypoxic relative intensity (NR) and normoxia matched to hypoxic absolute intensity (NA). Blood samples were collected at baseline, immediately post\u2010HIIE and at 3 and 24 h post\u2010exercise. Both NW and OW groups had significant reductions in peak heart rate and peak power output in hypoxic versus normoxic GXT (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). The NW group showed a greater decline in peak oxygen uptake  under hypoxia compared to OW (\u0394\u00a0=\u00a09.88\u00a0\u00b1\u00a05.0 vs. 5.22\u00a0\u00b1\u00a03.3\u00a0mL\u00a0\u00b7\u00a0kg\u00a0\u00b7\u00a0min<jats:sup>\u22121<\/jats:sup>; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). OW exhibited increased blood glucose levels post\u2010hypoxic GXT compared to normoxic conditions (\u0394\u00a0=\u00a00.358\u00a0mmol\u00a0\u00b7\u00a0L<jats:sup>\u22121<\/jats:sup>; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.025). During HIIE sessions, both groups showed similar heart rate, oxygen consumption, carbon dioxide production and respiratory exchange ratio responses. However, blood lactate concentration immediately after normoxic HIIE (NR) was higher in NW compared to OW (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). Fasting blood glucose significantly increased immediately after normoxic HIIE in NW and immediately after hypoxic HIIE in OW (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). HIIE in normoxia and hypoxia elicits similar physiological responses across BMI categories, though normal\u2010weight individuals have greater reductions in  and higher lactate responses during normoxic HIIE (NR), whereas overweight\/obese individuals exhibit higher glucose increases post\u2010hypoxic exercise, indicating potential BMI\u2010specific metabolic benefits. These findings suggest that BMI could influence physiological adaptations in response to high\u2010intensity exercise in hypoxia, suggesting that this form of exercise could be a beneficial alternative for improving metabolic health, especially in individuals with overweight or obesity.<\/jats:p>","DOI":"10.1002\/ejsc.70016","type":"journal-article","created":{"date-parts":[[2025,7,18]],"date-time":"2025-07-18T16:59:41Z","timestamp":1752857981000},"source":"Crossref","is-referenced-by-count":0,"title":["Physiological Responses to High\u2010Intensity Interval Exercise in Hypoxia Among Lean Males and Those With Overweight or Obesity"],"prefix":"10.1002","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9127-416X","authenticated-orcid":false,"given":"Zhenhuan","family":"Wang","sequence":"first","affiliation":[{"name":"Key Laboratory of General Administration of Sport Southwest University  Chongqing China"},{"name":"Institute for Health and Sport Victoria University  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