{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T02:26:09Z","timestamp":1777947969385,"version":"3.51.4"},"reference-count":57,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:00:00Z","timestamp":1773273600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:00:00Z","timestamp":1773273600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Sport Science"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    To examine the acute effect of gliclazide on exercise performance and recovery of muscle strength in healthy participants. We conducted a randomized, double\u2010blind, placebo\u2010controlled crossover clinical trial in 44 strength\u2010trained men. They were allocated to gliclazide modified release (MR) (90\u00a0mg, 8h before exercise sessions) or placebo, undergo three consecutive sessions of strength exercise (four sets, 80% of one\u2010repetition maximum [1\u2010RM] of bench press and free squat exercise). We evaluated total volume\u2010load (VL) (#repetitions x 80%1\u2010RM), range of motion (ROM), insulin and glucose levels, creatine kinase MM (CK\u2010MM), lactate dehydrogenase (LDH), interleukin\u20106 (IL\u20106) and tumor necrosis factor alpha (TNF\u2010\u03b1), hemodynamic parameters, perceived muscle soreness and recovery scores. Gliclazide enhanced strength exercise performance with improvements in total VL (bench press 23.3%,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.001; squat 23.2%,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.001), and improved muscle recovery 24\u201348h post\u2010exercise: ROM (shoulder 1.1%,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.001; knee 1.6%,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.004), CK\u2010MM (\u221213.2%,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.001), LDH (\u221212.8%,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.001), TNF\u2010\u03b1 (\u221217.4%,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.001), IL\u20106 (\u22125.3%,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.001), muscle soreness (\u221217.7%,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.001) and recovery scores (32.5%,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.001). However, hypoglycemia events were observed in 3 participants in the gliclazide group. In conclusion, Gliclazide MR 90\u00a0mg, 8h before strength exercise, produced ergogenic effects (exercise performance and muscle recovery), although hypoglycemia was observed in 7% of subjects.\n                    <jats:bold>Registration<\/jats:bold>\n                    : \u201c\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.clinicaltrials.gov\">www.clinicaltrials.gov<\/jats:ext-link>\n                    \u201d, \u201cNCT04443777\u201d (Primary Completion: 01\/08\/2020; Study Completion: 31\/10\/2023)\n                  <\/jats:p>","DOI":"10.1002\/ejsc.70155","type":"journal-article","created":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T19:29:41Z","timestamp":1773343781000},"source":"Crossref","is-referenced-by-count":0,"title":["Gliclazide Enhances Exercise Performance and Recovery of Muscle Strength in Healthy Trained Individuals: A Randomized Controlled Trial"],"prefix":"10.1002","volume":"26","author":[{"given":"Jocelito Bijoldo","family":"Martins","sequence":"first","affiliation":[{"name":"Instituto de Cardiologia do Rio Grande do Sul\/Funda\u00e7\u00e3o Universit\u00e1ria de Cardiologia  Porto Alegre RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thiago","family":"Dipp","sequence":"additional","affiliation":[{"name":"Instituto de Cardiologia do Rio Grande do Sul\/Funda\u00e7\u00e3o Universit\u00e1ria de Cardiologia  Porto Alegre RS Brazil"},{"name":"Programa de Pos\u2010Gradua\u00e7\u00e3o em Sa\u00fade Coletiva Universidade do Vale do Rio dos Sinos  S\u00e3o Leopoldo Rio Grande do Sul Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatriz D.","family":"Schaan","sequence":"additional","affiliation":[{"name":"Hospital de Cl\u00ednicas de Porto Alegre  Porto Alegre RS Brazil"},{"name":"Universidade Federal do Rio Grande do Sul  Porto Alegre RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5912-8020","authenticated-orcid":false,"given":"Alexandre Machado","family":"Lehnen","sequence":"additional","affiliation":[{"name":"Instituto de Cardiologia do Rio Grande do Sul\/Funda\u00e7\u00e3o Universit\u00e1ria de Cardiologia  Porto Alegre RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,12]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e3181915670"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00421\u2010017\u20103598\u20109"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1519\/jsc.0000000000003167"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2010.179"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1519\/jsc.0000000000001511"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1113\/EP088188"},{"key":"e_1_2_11_8_1","volume-title":"Goldman's Cecil Medicine, Expert Consult Premium Edition\u2010\u2010Enhanced Online Features and Print, Single Volume, 24: Goldman's Cecil Medicine","author":"Cecil R. 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