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Twelve males (mean\u00a0\u00b1\u00a0SD; : 52.2\u00a0\u00b1\u00a06.9\u00a0mL\/kg\/min) ran \u223c8.0\u00a0km: (i) at the velocity associated to the respiratory compensation point (vRCP; 5\u00a0\u00d7\u00a08\u00a0min bouts \u2012 RUN\n                    <jats:sub>100%RCP<\/jats:sub>\n                    ); (ii) at 30% above vRCP (10\u00a0\u00d7\u00a03\u00a0min bouts \u2012 RUN\n                    <jats:sub>130%RCP<\/jats:sub>\n                    ); and (iii) at 50% above vRCP (20\u00a0\u00d7\u00a080\u00a0s bouts \u2012 RUN\n                    <jats:sub>150%RCP<\/jats:sub>\n                    ). Before and for 6\u00a0h post\u2010exercise, voluntary and evoked contractions of knee\u2010extensors were assessed, alongside tiredness, leg pain, and perceived recovery. Following all protocols, voluntary activation remained depressed for up to 4\u00a0h post\u2010exercise, while voluntary peak force was reduced for at least 6\u00a0h (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.05). Other neuromuscular function markers reduced (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.05) according to the protocol. No time \u00d7 protocol interaction was observed for any neuromuscular function marker (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&gt;\u00a00.05). Aggregate data (protocol effect,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.05) evidenced greater reduction in neural drive to\n                    <jats:italic>vastus lateralis<\/jats:italic>\n                    (RMS\n                    <jats:sub>VL<\/jats:sub>\n                    \/Mw\n                    <jats:sub>amp<\/jats:sub>\n                    ) after RUN\n                    <jats:sub>100%RCP<\/jats:sub>\n                    (\u221220%) compared to RUN\n                    <jats:sub>130%RCP<\/jats:sub>\n                    (\u22123%) and RUN\n                    <jats:sub>150%RCP<\/jats:sub>\n                    (\u22127%); and greater reduction in late rate of force development (RFD; 100\u2013200\u00a0ms) and contractile function (Qtw\n                    <jats:sub>pot<\/jats:sub>\n                    ) after RUN\n                    <jats:sub>150%RCP<\/jats:sub>\n                    (\u221218% and \u22128%, respectively) than RUN\n                    <jats:sub>100%RCP<\/jats:sub>\n                    (\u22128% and \u22122%, respectively). Leg pain and tiredness remained elevated (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.05) for at least 6\u00a0h following all protocols. Leg pain and tiredness were greater for up to 4\u00a0h and for at least 6\u00a0h, respectively, after RUN\n                    <jats:sub>150%RCP<\/jats:sub>\n                    than RUN\n                    <jats:sub>100%RCP<\/jats:sub>\n                    (time \u00d7 protocol interaction;\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.05). The choice of exercise protocol influences the extent of reduction in\n                    <jats:italic>vastus lateralis<\/jats:italic>\n                    neural drive, impairments in knee\u2010extensors contractile function, and perceived fatigability for hours following a high\u2010intensity endurance running.\n                  <\/jats:p>","DOI":"10.1002\/ejsc.70176","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T07:01:21Z","timestamp":1785135681000},"source":"Crossref","is-referenced-by-count":1,"title":["Neuromuscular Fatigue and Perceived Fatigability in the Hours Following a High\u2010Intensity Endurance Running Depend on the Exercise Protocol"],"prefix":"10.1002","volume":"26","author":[{"given":"Yago Medeiros","family":"Dutra","sequence":"first","affiliation":[{"name":"Laboratory of Physiology and Sport Performance (LAFIDE) School of Sciences S\u00e3o Paulo State University (UNESP)  Bauru 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