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Here, fast\u2010scan cyclic voltammetry at carbon\u2010fiber microelectrodes was used to uncover regional differences in dopamine (DA) release in the caudate putamen of R6\/2 and wild\u2010type control mice. We found a decreasing ventral\u2010to\u2010dorsal gradient in DA release, evoked by a single electrical stimulus pulse, in aged R6\/2 mice. Moreover, under more intense stimulation conditions (120 pulses), DA release was significantly attenuated in the dorsal, but not in the ventral caudate. Autoradiography measurements using [<jats:sup>3<\/jats:sup>H] WIN 35,428 revealed that the overall density of DA transporter (DAT) protein molecules was significantly less in R6\/2 mice compared to WT control mice; however, quadrants of the caudate putamen were not differentially altered in the R6\/2 mice. These data collectively suggest that DA release in the dorsal caudate region is more vulnerable with age progression compared to the ventral region.<\/jats:p>","DOI":"10.1002\/elan.201700827","type":"journal-article","created":{"date-parts":[[2018,3,30]],"date-time":"2018-03-30T06:19:27Z","timestamp":1522390767000},"page":"1066-1072","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Regional Differences in Dopamine Release in the R6\/2 Mouse Caudate Putamen"],"prefix":"10.1002","volume":"30","author":[{"given":"Sam V.","family":"Kaplan","sequence":"first","affiliation":[{"name":"Department of Chemistry, R. N. Adams Institute for Bioanalytical Chemistry University of Kansas  Lawrence, Kansas 66045 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan A.","family":"Limbocker","sequence":"additional","affiliation":[{"name":"Department of Chemistry, R. N. 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