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Twenty\u2010one proteolytically active enzymes were classified into four groups based on substrate specificities on benzoyl\u2010arginine\u2010ethylester (BAEE), <jats:italic>N<\/jats:italic>\u2010\u03b1\u2010benzoyl\u2010<jats:sc>DL<\/jats:sc>\u2010arginine\u2010<jats:italic>p<\/jats:italic>\u2010nitroanilide (BAPNA), and poly\u2010<jats:sc>L<\/jats:sc>\u2010lysine. These types were further divided into eight subgroups by their sensitivity to inhibitors and androgen dependence. 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