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This paper illustrates the use of UHG\u2010based DNA heteroduplex analysis by describing the construction, properties, and methods of use of five UHGs, designed for genetic screening and testing of the inherited metabolic diseases: phenylketonuria, sickle\u2010cell disease, cystic fibrosis, von Willebrand's disease type 2B, and mamman\u2010binding lectin deficiency. In all cases, identification of multiple disease\u2010associated genotypes is possible using a single UHG.<\/jats:p>","DOI":"10.1002\/elps.1150170143","type":"journal-article","created":{"date-parts":[[2005,5,28]],"date-time":"2005-05-28T10:55:57Z","timestamp":1117277757000},"page":"247-254","source":"Crossref","is-referenced-by-count":26,"title":["Genetic screening and testing by induced heteroduplex formation"],"prefix":"10.1002","volume":"17","author":[{"given":"Nigel","family":"Wood","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey","family":"Bidwell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,4,14]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.12.4397"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/313495a0"},{"key":"e_1_2_1_4_2","first-page":"337","volume":"45","author":"Nagamine C. 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