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Serum amyloid A protein spots were identified by immunoblotting with specific antiserum and by matching determined with predicted values of electrophoretic parameters. Changes in the concentrations of \u03b11\u2010antitrypsin, leucinerich glycoprotein, haptoglobin, serum retinol\u2010binding protein and transthyretin were quantitated by densitometry of silver\u2010stained gels. Electrophoretic patterns from 18 patients with bacterial diseases and 16 patients with viral diseases were compared. The incidence of serum amyloid A protein spots was 18\/18 in bacterial diseases and 6\/16 in viral diseases. 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