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Reaction of 1 with 2,3\u2010epoxy\u2010propyltrimethylammonium chloride gave preponderantly 6\u2010<jats:italic>O<\/jats:italic>\u2010(2\u2010hydroxy\u20103\u2010trimethyl\u2010ammoniopropyl) derivatives (2) of varying degrees of substitution (d.s.). Analogous reaction of 1 with 1,3\u2010propanesultone yielded 6\u2010<jats:italic>O<\/jats:italic>\u2010(sulfo\u2010<jats:italic>n<\/jats:italic>\u2010propyl) derivatives (SPE\u2010\u03b2\u2010CD, 3) of varying d.s. The purity and the d.s. of 2 and 3 were determined by <jats:sup>1<\/jats:sup>H NMR and electrospray ionization mass spectrometry (ESI\u2010MS). These charged \u03b2\u2010cyclodextrin derivatives were used for the chromatographic enantiomer separation of a series of neutral barbiturates, of chlorthalidone, terbutaline, warfarin, salbutamol and brompheniramine by cyclodextrin electrokinetic chromatography (CD\u2010EKC). 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