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Several factors were shown to affect both the selectivity and the migration time, including concentration of heparin, concentration of buffer, and the pH. A dual mechanism involving both inclusion complexation and ionic interactions with heparin is thought to be responsible for the chiral recognition. In the pH range of 2.6\u20133.5 and reversed polarity, baseline resolutions were obtained using a wide range of buffer and heparin concentrations. Typically, chiral resolution was obtained within 50 min.<\/jats:p>","DOI":"10.1002\/elps.1150191213","type":"journal-article","created":{"date-parts":[[2005,5,28]],"date-time":"2005-05-28T12:31:17Z","timestamp":1117283477000},"page":"2119-2123","source":"Crossref","is-referenced-by-count":29,"title":["Application of heparin to chiral separations of antihistamines by capillary electrophoresis"],"prefix":"10.1002","volume":"19","author":[{"given":"Yingkun","family":"Jin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Apryll M.","family":"Stalcup","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,4,14]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-78058-5"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(96)00836-9"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/elps.1150181220"},{"key":"e_1_2_1_5_2","first-page":"3","volume-title":"Chemistry and Biology of Heparin","author":"Lundblad R. 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