{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T14:07:02Z","timestamp":1783606022166,"version":"3.55.0"},"reference-count":12,"publisher":"Wiley","issue":"24","license":[{"start":{"date-parts":[[2002,12,12]],"date-time":"2002-12-12T00:00:00Z","timestamp":1039651200000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Electrophoresis"],"published-print":{"date-parts":[[2002,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Lipoic acid is a naturally occurring compound which is being widely investigated for its therapeutic effects in the treatment or prevention of a variety of diseases associated with oxidative injury, particularly diabetes. The diversity of therapeutic applications of lipoic acid requires an appropriate formulation to control its bioavailability, site\u2010targeting delivery and to overcome its inherent chemical instability. In this regard, cyclodextrins (CDs) are ideally suitable due to their well\u2010documented ability to include in their cavity proper guest molecules and protect them from physical or chemical damages. Lipoic acid forms 1:1 inclusion complexes with \u03b2CD as shown in a previous report of an extended investigation that also indicated the suitability of capillary zone electrophoresis (CZE) for the study of such host\u2010guest interactions. In view of these possible applications, we extended the CZE analysis to determine the strength of binding, in a pH\u00a09 phosphate buffer, of lipoic acid with other CD derivatives such as \u03b1CD, \u03b3CD and the alkylated derivatives of \u03b2CD, namely (2\u2010hydroxypropyl)\u2010\u03b2\u2010CD (HP\u03b2CD), and heptakis(2,3,6\u2010tri\u2010<jats:italic>O<\/jats:italic>\u2010methyl)\u2010\u03b2\u2010CD (TM\u03b2CD). Once established that the easily available \u03b2CD is the most suitable receptor for lipoic acid, we set up and here describe a simple and reliable procedure for the quantitative determination of lipoic acid in commercial dietary supplement tablets containing also other active substances and excipients.<\/jats:p>","DOI":"10.1002\/elps.200290029","type":"journal-article","created":{"date-parts":[[2002,12,13]],"date-time":"2002-12-13T09:25:44Z","timestamp":1039771544000},"page":"4117-4122","source":"Crossref","is-referenced-by-count":17,"title":["Capillary zone electrophoresis study of cyclodextrin \u2013 lipoic acid host\u2010guest interaction"],"prefix":"10.1002","volume":"23","author":[{"given":"Marco","family":"Trentin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tommaso","family":"Carofiglio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Fornasier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umberto","family":"Tonellato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,12,12]]},"reference":[{"key":"e_1_2_1_2_2","volume-title":"Lipoic Acid in Health and Disease","author":"Fuchs J.","year":"1997"},{"key":"e_1_2_1_3_2","volume-title":"Comprehensive Supramolecular Chemistry","author":"Fenyvesi E.","year":"1996"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/1099-0690(200204)2002:7<1191::AID-EJOC1191>3.0.CO;2-I"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1021\/js980458n"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00707889"},{"key":"e_1_2_1_7_2","first-page":"19","volume-title":"Lipic Acid in Health and Disease","author":"Fuchs J.","year":"1997"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/elps.1150171021"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.2116\/bunsekikagaku.46.503"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1021\/j100011a065"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja01102a001"},{"key":"e_1_2_1_12_2","volume-title":"High Performance Capillary Electrophoresis. Theory, Techniques, and Applications","author":"Khaledi M. G.","year":"1998"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/elps.1150181210"}],"container-title":["ELECTROPHORESIS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Felps.200290029","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/elps.200290029","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T13:51:05Z","timestamp":1760536265000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/elps.200290029"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,12]]},"references-count":12,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2002,12]]}},"alternative-id":["10.1002\/elps.200290029"],"URL":"https:\/\/doi.org\/10.1002\/elps.200290029","archive":["Portico"],"relation":{},"ISSN":["0173-0835","1522-2683"],"issn-type":[{"value":"0173-0835","type":"print"},{"value":"1522-2683","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,12]]}}}