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Although heptakis\u2010(2,6\u2010di\u2010<jats:italic>O<\/jats:italic>\u2010methyl)\u2010\u03b2\u2010cyclodextrin (DIMEB) was suitable for the enantioresolution of deprenyl and its dealkylated derivatives, the enantiomers of deprenyl\u2010<jats:italic>N<\/jats:italic>\u2010oxide were just partly resolved. Carboxymethyl\u2010\u03b2\u2010cyclodextrin (CMBCD) in as low as 2 m<jats:sc>M<\/jats:sc> concentration was capable of the enantiomer separation of all the nine examined compounds, however co\u2010migration of 1<jats:italic>R<\/jats:italic>,2<jats:italic>S<\/jats:italic>\u2010(\u2212)\u2010norephedrine and 1<jats:italic>R<\/jats:italic>,2<jats:italic>R<\/jats:italic>\u2010(\u2212)\u2010pseudoephedrine, as well as 1<jats:italic>S<\/jats:italic>,2<jats:italic>R<\/jats:italic>\u2010(+)\u2010ephedrine and <jats:italic>R<\/jats:italic>\u2010(\u2212)\u2010amphetamine was observed. This problem could be overcome by the use of a dual cyclodextrin system containing 4 m<jats:sc>M<\/jats:sc> DIMEB in addition to 2 m<jats:sc>M<\/jats:sc> CMBCD; simultaneous separation of all the compounds could be achieved. The optimized method was used for the analysis of rat urine samples after 10\u00a0days of treatment of animals with either <jats:italic>R<\/jats:italic>\u2010(\u2212)\u2010 or <jats:italic>S<\/jats:italic>\u2010(+)\u2010deprenyl. The stereospecific biotransformation of both deprenyl enantiomers was confirmed, and the stereoselectivity of <jats:italic>N<\/jats:italic>\u2010oxide formation was demonstrated.<\/jats:p>","DOI":"10.1002\/elps.200305468","type":"journal-article","created":{"date-parts":[[2003,7,31]],"date-time":"2003-07-31T10:15:28Z","timestamp":1059646528000},"page":"2665-2673","source":"Crossref","is-referenced-by-count":30,"title":["Chiral characterization of deprenyl\u2010<b><i>N<\/i><\/b>\u2010oxide and other deprenyl metabolites by capillary electrophoresis using a dual cyclodextrin system in rat urine"],"prefix":"10.1002","volume":"24","author":[{"given":"Tam\u00e1s","family":"T\u00e1bi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K\u00e1lm\u00e1n","family":"Magyar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c9va","family":"Sz\u00f6k\u0151","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,7,31]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(00)00134-5"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(99)01042-0"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/1522-2683(20000601)21:10<1953::AID-ELPS1953>3.0.CO;2-G"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/1522-2683(200109)22:15<3107::AID-ELPS3107>3.0.CO;2-Z"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(00)01124-9"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(99)01309-6"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(97)00700-0"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(00)00084-4"},{"key":"e_1_2_1_10_2","first-page":"154","volume":"155","author":"Knoll J.","year":"1965","journal-title":"Arch. 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