{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T15:22:15Z","timestamp":1760887335115,"version":"build-2065373602"},"reference-count":21,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2003,7,31]],"date-time":"2003-07-31T00:00:00Z","timestamp":1059609600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Electrophoresis"],"published-print":{"date-parts":[[2003,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We present a method for the stereoselective analysis of thioridazine 5\u2010sulfoxide (THD 5\u2010SO) in human plasma based on liquid\u2010liquid extraction with diethyl ether and chiral resolution of the stereoisomers by capillary electrophoresis using hydroxypropyl\u2010\u03b2\u2010cyclodextrin and sulfated \u03b2\u2010cyclodextrin as chiral selectors. The method showed recovery rates of 85.5% for both THD 5\u2010SO (slow\u2010eluting, SE) enantiomers. The coefficients of variation observed in the precision studies, as well as the accuracy values, were below 10%. After validation, the method was used to study the stability and configurational changes of this THD metabolite. Our results showed that both enantiomers of THD 5\u2010SO (SE) were stable under conditions of variation of temperatures (38\u00b0C, 4\u00b0C and \u221220\u00b0C), pH\u00a0(5.0, 7.0 and 8.5) and ionic strengths (0.2, 0.5 and 1.0\u00a0mol\/L). The influence of light on the stability of the THD 5\u2010SO (SE) stereoisomers was also studied using standard solutions prepared in methanol and an inversion in configuration was observed under UV light (254 and 366\u00a0nm).<\/jats:p>","DOI":"10.1002\/elps.200305480","type":"journal-article","created":{"date-parts":[[2003,7,31]],"date-time":"2003-07-31T10:15:28Z","timestamp":1059646528000},"page":"2723-2730","source":"Crossref","is-referenced-by-count":10,"title":["Study on thioridazine 5\u2010sulfoxide epimerization and degradation by capillary electrophoresis"],"prefix":"10.1002","volume":"24","author":[{"given":"Cristiane","family":"Masetto de Gaitani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre","family":"Souto Martinez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierina","family":"Sueli Bonato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,7,31]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/17.6.374"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3908(88)90006-8"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4347(95)00096-2"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600720610"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600610618"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(86)90398-4"},{"key":"e_1_2_1_8_2","first-page":"100","volume":"27","author":"Heath A.","year":"1985","journal-title":"Vet. 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