{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T23:26:16Z","timestamp":1792193176195,"version":"4.4.0"},"reference-count":19,"publisher":"Wiley","issue":"24","license":[{"start":{"date-parts":[[2003,12,12]],"date-time":"2003-12-12T00:00:00Z","timestamp":1071187200000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Electrophoresis"],"published-print":{"date-parts":[[2003,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:sc>D<\/jats:sc>\u2010Penicillamine is demonstrated for the first time as a chiral ligand for the enantioseparation of dansyl amino acids based on ligand\u2010exchange micellar electrokinetic chromatography (LE\u2010MEKC). Copper(II) was used as the central ion in the ternary complex. The effect of surfactant on the resolution was significant. A concentration of 20\u00a0m<jats:sc>M<\/jats:sc> sodium dodecyl sulfate (SDS) was shown to be necessary for the separation. Other important parameters, such as the concentration ratio of <jats:sc>D<\/jats:sc>\u2010penicillamine (<jats:sc>D<\/jats:sc>\u2010PEN) to Cu<jats:sup>2+<\/jats:sup>, the kind of metal central ion, the type and pH value of buffer, were also investigated. <jats:italic>N<\/jats:italic>\u2010Acetyl\u2010<jats:sc>D<\/jats:sc>\u2010penicillamine and <jats:sc>L<\/jats:sc>\u2010valine (Val), with similar structure to D\u2010penicillamine, were applied as their copper(II) complexes as chiral selector and the chiral recognition mechanism is briefly discussed. Under optimum experimental conditions, <jats:italic>i.e.<\/jats:italic>, 20\u00a0m<jats:sc>M<\/jats:sc> NH<jats:sub>4<\/jats:sub>OAc, pH\u00a06.5, a 2:1 concentration ratio of <jats:sc>D<\/jats:sc>\u2010penicillamine to Cu(II), 4\u00a0m<jats:sc>M<\/jats:sc> CuSO<jats:sub>4<\/jats:sub> and 8\u00a0m<jats:sc>M<\/jats:sc> <jats:sc>D<\/jats:sc>\u2010penicillamine, the chiral separation of eight pairs of different dansyl amino acid enantiomers was accomplished with resolution ranging from 1.1 to 5.9. When <jats:sc>L<\/jats:sc>\u2010PEN was used instead of <jats:sc>D<\/jats:sc>\u2010PEN, reversal of the migration order was observed.<\/jats:p>","DOI":"10.1002\/elps.200305610","type":"journal-article","created":{"date-parts":[[2003,12,12]],"date-time":"2003-12-12T07:01:50Z","timestamp":1071212510000},"page":"4221-4226","source":"Crossref","is-referenced-by-count":31,"title":["Chiral separation with ligand\u2010exchange micellar electrokinetic chromatography using a <scp>D<\/scp>\u2010penicillamine\u2010copper(II) ternary complex as chiral selector"],"prefix":"10.1002","volume":"24","author":[{"given":"Zhi\u2010Xia","family":"Zheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin\u2010Ming","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiyuki","family":"Hobo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,12,12]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/S0021-9673(00)95566-3","volume":"60","author":"Davankov V. A.","year":"1971","journal-title":"J. Chromatogr."},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.230.4727.813"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1021\/ac00128a009"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02688463"},{"key":"e_1_2_1_6_2","first-page":"23","volume":"1","author":"Schmid M. G.","year":"1996","journal-title":"Enantiomer"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1520-667X(1999)11:7<534::AID-MCS5>3.0.CO;2-A"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.2116\/analsci.16.131"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.63"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-2670(99)00565-6"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1021\/ac00265a031"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1021\/ac00281a014"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(01)83299-4"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(98)00350-1"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02467620"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(01)01494-7"},{"key":"e_1_2_1_17_2","first-page":"1396","volume":"26","author":"Dash S.","year":"1999","journal-title":"J. Rheumatol."},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8257(199907)14:4<545::AID-MDS1001>3.0.CO;2-U"},{"key":"e_1_2_1_19_2","volume-title":"Micellar Electrokinetic Chromatography","author":"Terabe S.","year":"1993"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02276847"}],"container-title":["ELECTROPHORESIS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Felps.200305610","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/elps.200305610","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T13:37:53Z","timestamp":1760535473000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/elps.200305610"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,12]]},"references-count":19,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2003,12]]}},"alternative-id":["10.1002\/elps.200305610"],"URL":"https:\/\/doi.org\/10.1002\/elps.200305610","archive":["Portico"],"relation":{},"ISSN":["0173-0835","1522-2683"],"issn-type":[{"value":"0173-0835","type":"print"},{"value":"1522-2683","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,12]]}}}