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Three octadecylsilanized (ODS) silica gel\u2010based stationary phases, differing in particle diameter and carbon surface density for suitability of determination of the enantiomeric composition of these substances in drugs and biological fluids, were studied. Under optimum separation conditions, all the investigated compounds were baseline\u2010resolved within acceptable analysis times (<jats:italic>i.e.<\/jats:italic>, between 10\u201316\u00a0min). The resolution values ranged between 1.80 and 1.14, and the separation factors were in no case less than 1.07. The possible use of the developed CEC method for the determination of enantiomeric composition of \u03b2\u2010adrenoreceptor blocking agents in drug substances was investigated. A study, in which the enantiomers of metoprolol were examined regarding specificity, reproducibility, limit of detection, and ruggedness, was developed in accordance with some analytical procedures for method validation.<\/jats:p>","DOI":"10.1002\/elps.200305691","type":"journal-article","created":{"date-parts":[[2004,2,18]],"date-time":"2004-02-18T12:02:15Z","timestamp":1077105735000},"page":"607-614","source":"Crossref","is-referenced-by-count":12,"title":["Indirect resolution of \u00df\u2010blocker agents by reversed\u2010phase capillary electrochromatography"],"prefix":"10.1002","volume":"25","author":[{"given":"Zeineb","family":"Aturki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Vichi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonella","family":"Messina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Sinibaldi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,2,16]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/2101336a0"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo00413a002"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/chir.530010103"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0731-7085(92)80057-T"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/jhrc.1240090910"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0731-7085(91)80097-S"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4347(94)00295-9"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9673(95)00384-Y"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9673(94)00886-8"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9673(94)00782-9"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1080\/10826079208017191"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9673(94)87009-8"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(01)87131-4"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1039\/an9911601343"},{"key":"e_1_2_1_16_2","first-page":"142","volume-title":"Advanced Chromatographic and Electromigration Methods in BioSciences","author":"Deyl Z.","year":"1998"},{"key":"e_1_2_1_17_2","first-page":"384","volume-title":"CRC Handbook of HPLC for the Separation of Amino Acids, Peptides and Proteins","author":"Nambara T.","year":"1984"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1021\/ac00135a025"},{"key":"e_1_2_1_19_2","first-page":"10","volume":"6","author":"Sanchez D.","year":"1988","journal-title":"Janssen Chim. 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