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The separation was optimized in a 75\u00a0\u03bcm ID capillary, packed with 3\u2010(1,8\u2010naphthalimido)propyl\u2010modified silyl silica gel (NAIP), studying the effect of buffer pH, buffer concentration, and mobile phase composition. Using an applied voltage of 20 kV and the short\u2010end injection method (9\u00a0cm capillary effective length), the mobile phase of 1.0\u00a0m<jats:sc>M<\/jats:sc> citrate buffer (pH 5.0) containing 40% methanol provided the baseline separation of barbital, phenobarbital, secobarbital, and thiopental (internal standard) in less than 4.5\u00a0min. The method was successfully applied to the analysis of barbiturates in human serum. Under the optimal conditions, good repeatability and linearity were obtained in the range of 2.90\u201343.29\u00a0\u03bcg\/mL for barbital, phenobarbital, and secobarbital.<\/jats:p>","DOI":"10.1002\/elps.200305703","type":"journal-article","created":{"date-parts":[[2004,2,18]],"date-time":"2004-02-18T12:02:15Z","timestamp":1077105735000},"page":"594-599","source":"Crossref","is-referenced-by-count":27,"title":["Capillary electrochromatographic analysis of barbiturates in serum"],"prefix":"10.1002","volume":"25","author":[{"given":"Kaname","family":"Ohyama","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuhiro","family":"Wada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gwyn A.","family":"Lord","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihito","family":"Ohba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osamu","family":"Fujishita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenichiro","family":"Nakashima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang Kee","family":"Lim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naotaka","family":"Kuroda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,2,16]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1520\/JFS16153J","volume":"43","author":"Collison I. 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