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The review is concerned with molecules of mass less than 500\u2005Da, chosen according to selected structural classes in which they give ESI signals primarily as [M+H]<jats:sup>+<\/jats:sup>\u2005ions although other ions, such as [M\u2212H]<jats:sup>\u2212<\/jats:sup>, [M+Na]<jats:sup>+<\/jats:sup>, and [M+NH<jats:sub>4<\/jats:sub>]<jats:sup>+<\/jats:sup>, are also reported. These structural classes are drugs with amine\u2010containing side chains, drugs with <jats:italic>N<\/jats:italic>\u2010containing saturated ring structures, 1,4\u2010benzodiazepines, other heterocyclic hypnotics, carbohydrates, sulphonylureas, anthracyclines, sulphonamides, penicillins, cephalosporins, tetracyclines, nitrocatechols, steroids, flavonoids\/polyphenols, cannabinols, and miscellaneous molecules. Details are given on the fragmentations, where available, that these ionic species exhibit in\u2010source and in ion\u2010trap, triple quadrupole, and time of flight\u2010mass spectrometers. The review gives a critical evaluation of these recent CE\u2010ESI\u2010MS analytical methods in drug analysis. Analytical information on, for example, sample concentration techniques, CE separation conditions, recoveries from biological media and limits of detection (LODs) are provided. Potential applications of CE\u2010MS to particular drugs or drug classes are also briefly discussed in the text.<\/jats:p>","DOI":"10.1002\/elps.200406202","type":"journal-article","created":{"date-parts":[[2005,3,10]],"date-time":"2005-03-10T11:39:09Z","timestamp":1110454749000},"page":"1334-1357","source":"Crossref","is-referenced-by-count":61,"title":["Recent applications of capillary electrophoresis\u2010electrospray ionisation\u2010mass spectrometry in drug analysis"],"prefix":"10.1002","volume":"26","author":[{"given":"W. 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