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The stationary phase was 3\u2010(1,8\u2010naphthalimido) propyl\u2010modified silyl silica gel (NAIP) and the best separations were achieved with 4.0\u00a0m<jats:sc>M<\/jats:sc> citrate buffer (pH\u00a05.0) containing 80% methanol at an applied voltage of 25\u00a0kV. The compounds were completely separated in less than 3.5\u00a0min with good repeatability, which was approximately 3\u2010times less than that in high\u2010performance liquid chromatography (HPLC) with NAIP. The proposed method coupled with microdialysis was successfully applied to the monitoring of caffeine concentration in rat brain with detection limits of 1.11\u00a0\u03bcg\/mL.<\/jats:p>","DOI":"10.1002\/elps.200410292","type":"journal-article","created":{"date-parts":[[2005,2,15]],"date-time":"2005-02-15T09:49:06Z","timestamp":1108460946000},"page":"812-817","source":"Crossref","is-referenced-by-count":7,"title":["Capillary electrochromatography of caffeine and its metabolites in rat brain microdialysate"],"prefix":"10.1002","volume":"26","author":[{"given":"Kaname","family":"Ohyama","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuhiro","family":"Wada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gwyn 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