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The etiology of the disease is unknown but recent epidemiological and experimental studies have renewed interest in the hypothesis that environmental factors, especially herbicides and metals, have a role on the pathogenesis of PD. For the first time, the association constants of \u03b1\u2010synuclein with five herbicides have been calculated using a capillary electrophoresis (CE) method. In addition, the effect of a number of metals on this binding has been investigated. It appears that the herbicides preferentially bind to a partially folded intermediate conformation of \u03b1\u2010synuclein induced by manganese, aluminium, cadmium, copper and zinc. Then, metal increases the synuclein\u2013herbicide association. However, this study shows contrasting actions with the antibiotic rifampicin and magnesium addition leading to a decrease of the \u03b1\u2010synuclein\u2013herbicide interaction even if other metals are present in the bulk solvent. Considering epidemiological studies, all these results suggest an underlying molecular basis for PD and related body diseases.<\/jats:p>","DOI":"10.1002\/elps.200500169","type":"journal-article","created":{"date-parts":[[2005,9,5]],"date-time":"2005-09-05T09:47:54Z","timestamp":1125913674000},"page":"3256-3264","source":"Crossref","is-referenced-by-count":28,"title":["Effect of metals on herbicides\u2013\u03b1\u2010synuclein association: A possible factor in neurodegenerative disease studied by capillary electrophoresis"],"prefix":"10.1002","volume":"26","author":[{"given":"Claire","family":"Andr\u00e9","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tong T.","family":"Truong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean Francois","family":"Robert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yves C.","family":"Guillaume","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,9,5]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-199603000-00001"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(95)90302-X"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/42166"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.11.6469"},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","first-page":"3045","DOI":"10.1126\/science.276.5321.2045","volume":"276","author":"Polymeropoulos M. 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