{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T22:55:44Z","timestamp":1792018544113,"version":"4.4.0"},"reference-count":35,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2007,4,27]],"date-time":"2007-04-27T00:00:00Z","timestamp":1177632000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Electrophoresis"],"published-print":{"date-parts":[[2007,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In this work, simultaneous separation of eight stereoisomers of ephedrine and related compounds ((\u00b1)\u2010ephedrine, (\u00b1)\u2010pseudoephedrine, (\u00b1)\u2010norephedrine and (\u00b1)\u2010<jats:italic>N<\/jats:italic>\u2010methylephedrine) was accomplished using a polymeric chiral surfactant, <jats:italic>i.e<\/jats:italic>. polysodium <jats:italic>N<\/jats:italic>\u2010undecenoxycarbonyl\u2010<jats:sc>L<\/jats:sc>\u2010leucinate (poly\u2010<jats:sc>L<\/jats:sc>\u2010SUCL) by chiral (C)MEKC\u2010ESI\u2010MS. The conditions of CMEKC were first investigated. The baseline separation of all eight stereoisomers of ephedrine and related compounds was achieved under optimum CMEKC conditions (35\u2005mM poly\u2010<jats:sc>L<\/jats:sc>\u2010SUCL, 15\u2005mM NH<jats:sub>4<\/jats:sub>OAc, pH\u20056.0, 30% v\/v ACN, 30\u2005kV and 20\u00b0C) in less than 30\u2005min. Next, a central composite design for response surface modeling has been described to evaluate the electrospray chamber parameters and the sheath liquid conditions. Optimum mass abundance of stereoisomers of ephedrine and related compounds was observed using the spray chamber parameters, namely 250\u00b0C drying gas temperature and 8\u2005L\/min drying gas flow rate at a nebulizer pressure of 4\u2005psi. Furthermore, the experimental design indicates that the optimum mass abundance of the stereoisomers of ephedrine and related compounds can be obtained using a sheath liquid containing 80:20 v\/v methanol\u2010water, 5\u2005mM NH<jats:sub>4<\/jats:sub>OAc at pH\u20058.5 delivered at 5\u2005\u00b5L\/min. Finally, compared to MEKC\u2010UV, the use of poly\u2010<jats:sc>L<\/jats:sc>\u2010SUCL in MEKC\u2010MS provided significantly higher sensitivity for stereoisomers of ephedrine and related compounds.<\/jats:p>","DOI":"10.1002\/elps.200600415","type":"journal-article","created":{"date-parts":[[2007,4,27]],"date-time":"2007-04-27T07:22:10Z","timestamp":1177658530000},"page":"1352-1363","source":"Crossref","is-referenced-by-count":51,"title":["Simultaneous chiral separation and determination of ephedrine alkaloids by MEKC\u2010ESI\u2010MS using polymeric surfactant I: Method development"],"prefix":"10.1002","volume":"28","author":[{"given":"Jingguo","family":"Hou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed A. 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