{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:36:53Z","timestamp":1790620613754,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2007,3,19]],"date-time":"2007-03-19T00:00:00Z","timestamp":1174262400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Electrophoresis"],"published-print":{"date-parts":[[2007,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A rapid, high\u2010resolution and effective new method for analyzing 12 diuretics by CE\u2010ESI\u2010MS was established in this paper. Ten diuretics (except two neutral compounds) could be fast separated by CE with a DAD at 214\u2005nm with a 20\u2005kV voltage within 6 min, using a 50\u2005\u03bcm id and 48.5\u2005cm effective length uncoated fused\u2010silica capillary in a 40\u2005mM ammonium formate buffer (pH\u20059.40). CE was coupled to the mass spectrometer applying an orthogonal electrospray interface with a triple\u2010tube sheath liquid arrangement. The sheath liquid was composed of isopropanol\u2010water (1:1 v\/v) containing 30\u2005mM acetic acid with a flow rate of 4\u2005\u03bcL\/min. Mass spectrum was employed in the positive mode and both full scan mode and SIM scan mode were utilized. All 12 diuretics could be detected and confirmed by MS in a single analysis. Under optimized conditions, LODs for the 12 diuretics were in the range of 0.13\u20132.7\u2005\u00b5mol\/L at an S\/N of 3, and the correlation coefficients <jats:italic>R<\/jats:italic><jats:sup>2 <\/jats:sup>were between 0.9921 and 0.9978. The RDSs (<jats:italic>n<\/jats:italic>\u2005=\u20055) of the method was 0.24\u20130.94 % for migration times and 1.6\u20138.8 % for peak areas. The recoveries of spiked samples of 12 diuretics were between 72.4% and 118%. The real urine samples were injected directly for analysis, with only simple filtration through a 0.22\u2005\u00b5m membrane filter in order to remove solid particles, which may cause capillary blockage. Based on the migration times and characteristic ions, the diuretics in urine samples were detected successfully. This CE\u2010ESI\u2010MS method for analyzing diuretics will hopefully be applied to doping control.<\/jats:p>","DOI":"10.1002\/elps.200600543","type":"journal-article","created":{"date-parts":[[2007,3,19]],"date-time":"2007-03-19T07:34:56Z","timestamp":1174289696000},"page":"1461-1471","source":"Crossref","is-referenced-by-count":28,"title":["A new method for screening and determination of diuretics by on\u2010line CE\u2010ESI\u2010MS"],"prefix":"10.1002","volume":"28","author":[{"given":"Minghua","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shifei","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guonan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,4,27]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9673(95)01267-2"},{"key":"e_1_2_1_3_2","first-page":"315","volume-title":"Peking University Medical Press","author":"Yang Z. 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