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One hundred and seventy\u2010five consistently differentially expressed proteins were identified out of more than 1600 protein spots <jats:italic>per<\/jats:italic> gel. Of these 175 protein spots, 38 of the 41 most highly expressed proteins were identified by MS analysis (MALDI\u2010TOF), involving different cellular programs such as DNA repair (<jats:italic>Rad50<\/jats:italic>), cell cycle control (<jats:italic>Mad1L1<\/jats:italic>), transcription (<jats:italic>SAFB<\/jats:italic>), and apoptosis (Luca\u201015 protein). Expression data were confirmed by Western blot analysis of identified proteins and 2\u2010D gel hybridization of proteins with known overexpression (G1\/S\u2010specific cyclin\u2010D1, apoptosis regulator Bcl\u20102). Comparison of proteome analysis to RNA expression array data revealed only a modest correlation of RNA and protein level emphasizing the relevance of post\u2010translational regulation in lymphomagenesis (<jats:italic>p<\/jats:italic>\u2005=\u20050.36). Most interestingly, additional data bank search identified 13 out of 17 referenced proteins (76%) as members of a <jats:italic>TP53<\/jats:italic>\u2010dependent network of cell regulation.<\/jats:p>","DOI":"10.1002\/elps.200600831","type":"journal-article","created":{"date-parts":[[2007,11,7]],"date-time":"2007-11-07T10:20:26Z","timestamp":1194430826000},"page":"4416-4426","source":"Crossref","is-referenced-by-count":18,"title":["Proteome\u2010 and microarray\u2010based expression analysis of lymphoma cell lines identifies a p53\u2010centered cluster of differentially expressed proteins in mantle cell and follicular lymphoma"],"prefix":"10.1002","volume":"28","author":[{"given":"Marc","family":"Weinkauf","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maximilian","family":"Christopeit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Hiddemann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Dreyling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,11,26]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"86","volume":"145","author":"Yang W. 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